Results 31 to 40 of about 4,376,271 (343)

Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale [PDF]

Nucleic Acids Research, 2012
Methylation of a CpG island is a faithful marker of silencing of its associated gene. Different approaches report the methylation status of a CpG island based on the determination of one or a few CpG sites by assuming the homogeneity of methylation along the element.
Victor Barrera, Miguel A. Peinado
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Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites [PDF]

Genome Research, 2015
Long interspersed elements (LINEs), through both self-mobilization and trans-mobilization of short interspersed elements and processed pseudogenes, have made an indelible impact on the structure and function of the human genome. One consequence is the creation of new CpG islands (CGIs).
Leanne S. Whitmore, Xiaoling Jiang, Simon J. Newkirk, Simon J. Newkirk, Zoltán Ivics, Jun Yin, Zsuzsanna Izsvák, Sanum Bashir, Y. Eugene Yu, Fiorella C. Grandi, Zhuo Xing, James M. Rosser, Wenfeng An, Ping Ye   +13 more
openaire   +5 more sources

Hypermutable non-synonymous sites are under stronger negative selection. [PDF]

PLoS Genetics, 2008
Mutation rate varies greatly between nucleotide sites of the human genome and depends both on the global genomic location and the local sequence context of a site. In particular, CpG context elevates the mutation rate by an order of magnitude.
Steffen Schmidt, Anna Gerasimova, Fyodor A Kondrashov, Ivan A Adzhubei, Ivan A Adzuhbei, Alexey S Kondrashov, Shamil Sunyaev   +6 more
doaj   +1 more source

DNA unmethylome profiling by covalent capture of CpG sites [PDF]

Nature Communications, 2013
Dynamic patterns of cytosine-5 methylation and successive hydroxylation are part of epigenetic regulation in eukaryotes, including humans, which contributes to normal phenotypic variation and disease risk. Here we present an approach for the mapping of unmodified regions of the genome, which we call the unmethylome.
Kriukienė, Edita, Labrie, Viviane, Khare, Tarang, Urbanavičiūtė, Giedrė, Lapinaitė, Audronė, Koncevičius, Karolis, Li, Daofeng, Wang, Ting, Pai, Shraddha, Ptak, Carolyn, Gordevičius, Juozas, Wang, Sun-Chong, Petronis, Artūras, Klimašauskas, Saulius   +13 more
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Hyperconserved CpG domains underlie Polycomb-binding sites [PDF]

Proceedings of the National Academy of Sciences, 2007
Comparative genomics of CpG dinucleotides, which are targets of DNA methyltransferases in vertebrate genomes, has been constrained by their evolutionary instability and by the effect of methylation on their mutation rates. We compared the human and chimpanzee genomes to identify DNA sequence signatures correlated with rates of mutation at CpG ...
Marc Damelin, Amos Tanay, Anne H. O'Donnell, Timothy H. Bestor   +3 more
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Identification of Differentially Methylated CpG Sites in Fibroblasts from Keloid Scars [PDF]

Biomedicines, 2020
As a part of an abnormal healing process of dermal injuries and irritation, keloid scars arise on the skin as benign fibroproliferative tumors. Although the etiology of keloid scarring remains unsettled, considerable recent evidence suggested that keloidogenesis may be driven by epigenetic changes, particularly, DNA methylation.
Laith N. AL-Eitan, Suzanne Rea, Eric K. Moses, Eric K. Moses, Patricia L Danielsen, Janine M. Duke, Mansour A. Alghamdi, Andrew W. Stevenson, Hilary J. Wallace, Hilary J. Wallace, Mark W. Fear, Phillip E. Melton, Phillip E. Melton, Cecilia M Prêle, Fiona M. Wood, Fiona M. Wood   +15 more
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Site-specific antigen-adjuvant conjugation using cell-free protein synthesis enhances antigen presentation and CD8+ T-cell response

Scientific Reports, 2021
Antigen-adjuvant conjugation is known to enhance antigen-specific T-cell production in vaccine models, but scalable methods are required to generate site-specific conjugation for clinical translation of this technique.
Adam M. Weiss, Jainu Ajit, Tyler J. Albin, Neeraj Kapoor, Shilpa Maroju, Aym Berges, Lucy Pill, Jeff Fairman, Aaron P. Esser-Kahn   +8 more
doaj   +1 more source

Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome

Epigenetics, 2022
Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments. However, much less is known about the mouse epigenome, particularly for DNA methylation.
Garcia-Prieto, Carlos A., Álvarez-Errico, Damiana, Musulen, Eva, Bueno-Costa, Alberto, N. Vazquez, Berta, Vaquero, Alejandro, Esteller, Manel   +6 more
openaire   +7 more sources

DNA Methylation-Mediated Downregulation of DEFB1 in Prostate Cancer Cells. [PDF]

PLoS ONE, 2016
Epigenetic aberrations play crucial roles in prostate cancer (PCa) development and progression. The DEFB1 gene, which encodes human ß-defensin-1 (HBD-1), contributes to innate immune responses and functions as a potential tumor suppressor in urological ...
Jaehyouk Lee, Jun Hyun Han, Ara Jang, Jin Wook Kim, Soon Auck Hong, Soon Chul Myung   +5 more
doaj   +1 more source

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia

Frontiers in Cellular Neuroscience, 2015
Many encoded gene products responsible for neurodevelopmental disorders (NDs) like autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and idiopathic generalized epilepsy (IGE) converge on networks controlling synaptic ...
Nancy D. Merner, Madison R. Chandler, Cynthia V. Bourassa, Bo Liang, A. Khanna, P. Dion, G. Rouleau, K. Kahle   +7 more
semanticscholar   +1 more source