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Detection of CPSF6 in Biomolecular Condensates as a Reporter of HIV-1 Nuclear Import

The initial stages of HIV-1 infection involve the transport of the viral core into the nuclear compartment. The presence of the HIV-1 core in the nucleus triggers the translocation of CPSF6/CPSF5 from paraspeckles into nuclear speckles, forming puncta-like structures.
Charlotte, Luchsinger, Felipe, Diaz-Griffero +1 more
openaire +2 more sources

[The nuclear translocation of circRNA CPSF6 promotes apoptosis of trophoblast cells induced by homocysteine].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2022
Objective To investigate the role of circular RNA cleavage and polyadenylation specificity factor 6 (circRNA CPSF6) in the apoptosis of trophoblast cells induced by homocysteine (Hcy) and its mechanism. Methods HTR-8/SVneo human chorionic trophoblast cells were cultured in vitro and divided into control group (0 mmol/L Hcy treatment) and 1 mmol/L Hcy ...
Lina, Gao +8 more
openaire +1 more source

CPSF6 Loss Mediates LDHA 3’UTR Shortening to Promote Fibroblast Glycolysis and Pulmonary Fibrosis

Cellular Signalling
Pulmonary fibrosis is a chronic and progressive fibrotic lung disease with a poor prognosis and few treatment options. Alternative polyadenylation (APA), an important post-transcriptional regulatory mechanism, remains poorly understood in pulmonary fibrosis.
Huanyu, Yang +4 more
exaly +3 more sources

Deregulated Expression and Subcellular Localization of CPSF6, a circRNA-Binding Protein, Promote Malignant Development of Esophageal Squamous Cell Carcinoma

Journal of Semiconductors, 2022
Zitong Zhao, Qimin Zhan
exaly

The Oncogenic Role and Potential Treatment of a Novel CPSF6-Rarg Fusion in Myeloid Transformation