Results 181 to 190 of about 77,049 (267)

Risk of Age‐Related Ocular Diseases in Non‐Diabetic Adults With Obesity Using Glucagon‐Like Peptide 1 Receptor Agonists

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess whether glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are associated with a lower incidence of age‐related ocular diseases in non‐diabetic older adults with overweight or obesity. Materials and Methods We conducted a retrospective, propensity score–matched cohort study using the TriNetX global research network.
Kuo‐En Chen   +3 more
wiley   +1 more source

Harnessing Polygenic Risk Scores to Refine Venous Thromboembolism Risk Stratification

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Background Venous thromboembolism (VTE) is a major cause of morbidity in patients of all ages. Despite growing interest in polygenic risk scores (PRS) for VTE, their utility remains understudied. Our objective was to evaluate the independent impact of a PRS on VTE susceptibility in adults and children.
Katlyn G. McKay   +7 more
wiley   +1 more source

KU80 suppresses endonuclease G activity to preserve genomic integrity

open access: yesThe FEBS Journal, EarlyView.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan   +8 more
wiley   +1 more source

Do subjective and objective baseline sleep disturbances predict post-traumatic stress disorder treatment response? A secondary analysis of a randomized controlled trial. [PDF]

open access: yesEur J Psychotraumatol
Porten S   +9 more
europepmc   +1 more source

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

open access: yesThe FEBS Journal, EarlyView.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger   +3 more
wiley   +1 more source

Cervical musculoskeletal function is variable in tension‐type headache: A cluster analysis

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives This study was conducted to (1) consider the causes of neck pain in tension‐type headache (TTH) by investigating how the patients with TTH, idiopathic neck pain (INP), and healthy controls group together based on the presence of cervical musculoskeletal dysfunction; and (2) determine any differences in TTH features, pain sensitivity,
Chalomjai Pensri   +5 more
wiley   +1 more source

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