Results 131 to 140 of about 275,126 (317)
Histoire, Médecine et SantéThis article aims to trace how crack has been constructed as a “public issue” in France, particularly in the working-class neighborhoods in the North-East of Paris, by adopting a socio-historical perspective from 1986 to 2023.
Marie Jauffret-Roustide
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Análise das informações sobre a droga crack: o que divulgam os meios de comunicação? [PDF]
, 2015 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Saúde Coletiva, Florianópolis, 2015.A presente pesquisa teve como objetivos analisar informações sobre crack veiculadas em dois ...
Queiroz, Larissa de Abreu
core
Anales de la Facultad de Medicina, 2016 El consumo de pasta base de cocaína y marihuana durante el embarazo es un problema creciente. El objetivo de este estudio fue estimar la frecuencia del consumo de estas sustancias durante el embarazo en mujeres hospitalizados en el Hospital de Maldonado ...
María Claudia Cabrera +5 more
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Self-healing of Micro-cracks in Engineered Cementitious Composites
Civil Engineering Dimension, 2015 The performance of an Engineered Cementitious Composite (ECC) to self-heal micro-cracks under a controlled laboratory environment is presented. Ten dog-bone shaped samples were prepared; five of them were preloaded to known strains and then left to heal
Suryanto B., Wilson S.A., McCarter W.J.
doaj
A nonlocal elasticity theory to model the static behaviour of edge-cracked nanobeams
Fracture and Structural IntegrityIn the present paper, the mechanical behaviour of edge-cracked nanobeams under Mixed-Mode loading is analytically investigated by means of the Stress-Driven nonlocal model. Firstly, the proposed formulation is outlined, and then applied to the case of a
Daniela Scorza +5 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Fatigue Crack Control in Structural Details using surface peening [PDF]
, 2008 This paper presents an analytical and experimental study of crack shape evolution in steel plate specimens under cyclic loading. It is widely known that the introduction of compressive residual stresses by cold working the surface can be highly ...
Shi Song, Ngiam, Brennan, Feargal P.
core