Results 111 to 120 of about 338,464 (293)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effects of graphite nodules on crack growth behaviour of austempered ductile iron [PDF]

, 2007
Austempered ductile iron (ADI) is a candidate material for camshafts, where however, the early stages of fatigue damage are of major concern during service.
Reed, P.A.S., Gao, N., Stokes, B.
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

La construction du crack comme « problème public ». Socio-histoire des imaginaires sur des publics considérés comme « indésirables » (1986-2023)

Histoire, Médecine et Santé
This article aims to trace how crack has been constructed as a “public issue” in France, particularly in the working-class neighborhoods in the North-East of Paris, by adopting a socio-historical perspective from 1986 to 2023.
Marie Jauffret-Roustide
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Frecuencia y características de las embarazadas y los recién nacidos expuestos a marihuana y cocaína en la Maternidad del Hospital de Maldonado

Anales de la Facultad de Medicina, 2016
El consumo de pasta base de cocaína y marihuana durante el embarazo es un problema creciente. El objetivo de este estudio fue estimar la frecuencia del consumo de estas sustancias durante el embarazo en mujeres hospitalizados en el Hospital de Maldonado ...
María Claudia Cabrera, María José Pérez, Carlos Zunino, Yohany Cabana, Loreley García, Gustavo Giachetto   +5 more
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Self-healing of Micro-cracks in Engineered Cementitious Composites

Civil Engineering Dimension, 2015
The performance of an Engineered Cementitious Composite (ECC) to self-heal micro-cracks under a controlled laboratory environment is presented. Ten dog-bone shaped samples were prepared; five of them were preloaded to known strains and then left to heal
Suryanto B., Wilson S.A., McCarter W.J.
doaj  

A nonlocal elasticity theory to model the static behaviour of edge-cracked nanobeams

Fracture and Structural Integrity
In the present paper, the mechanical behaviour of edge-cracked nanobeams under Mixed-Mode loading is analytically investigated by means of the Stress-Driven nonlocal model. Firstly, the proposed formulation is outlined, and then applied to the case of a
Daniela Scorza, Andrea Carpinteri, Camilla Ronchei, Andrea Zanichelli, Sabrina Vantadori, Raimondo Luciano   +5 more
doaj   +1 more source

City of Cracks

Membrana – Journal of Photography, Theory and Visual Culture
Cities are constantly transforming due to different policy interventions, economic shifts, and climate change. In Eindhoven (NL), urban change is driven by the knowledge economy and an influx of highly skilled tech workers. Yet these transformations are uneven.
Anastasiya Ansteeg, Anaëlle Bueno Patin
openaire   +2 more sources