Results 121 to 130 of about 275,126 (317)

Characterization of crack nucleation in TA6V under fretting-fatigue loading using the potential drop technique [PDF]

, 2010
Crack initiation in a Ti-6Al-4V alloy was investigated experimentally in fretting fatigue conditions. A cylinder-plane geometry was used for the contact, and partial slip conditions were considered.
Deyber, S., S. Deyber, Kubiak, KJ, J. Meriaux, Kubiak, Krzysztof, Fouvry, S, S. Fouvry, Meriaux, J., K.J. Kubiak, Meriaux, J, Deyber, S, Fouvry, S.   +11 more
core   +1 more source

Analisa Kegagalan pada Fuel Intake Manifold Pesawat Terbang Boeing 737-500

Jurnal Teknik ITS, 2013
Fuel intake manifold merupakan komponen yang sangat penting di pesawat terbang dimana fuel intake manifold berfungsi sebagai penyalur bahan bakar yang akan dibawa ke engine.
Jeffri Malau, Rochman Rochiem
doaj  

Eigenfrequencies of the reinforced concrete beams – methods of calculations / Gelžbetoninių sijų tikriniai dažniai – skaičiavimo metodai

Journal of Civil Engineering and Management, 2011
The paper presents method of calculation of eigenfrequencies of the cracked reinforced concrete beams including discreet model of crack. The described method is based on the stiff finite elements method.
Mieczysław Kaminski, Michał Musiał, Andrzej Ubysz   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Buoyancy-driven crack propagation: the limit of large fracture toughness [PDF]

, 2007
We study steady vertical propagation of a crack filled with buoyant viscous fluid through an elastic solid with large effective fracture toughness. For a crack fed by a constant flux Q, a non-dimensional fracture toughness K=Kc/(3μQm3/2)1/4 describes the
Roper, S.M., S. M. ROPER, J. R. LISTER, Lister, J.R.   +3 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Investigation of crack propagation in X38CrMoV5 (AISI H11) tool steel at elevated temperatures [PDF]

, 2010
A method is developed to evaluate the surface fatigue damage of hot forming tools (forging, HPDC) that undergo thermo mechanical loading and environmental attack.
Rezaï-Aria, Farhad, Mabru, Catherine, Shah, Masood   +2 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The importance of geomechanics in oil and gas geology and in the processes of opening producing horizons

Мінеральні ресурси України, 2017
The role of geomechanical factors is shown by the specific examples, particularly the type of stress-strain state (SSS) of rocks on the formation of geological structures with the characteristics of reservoirs or lids, and also technogenic cracks around ...
Yu. I. Voitenko
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source