Results 101 to 110 of about 338,464 (293)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The social context of crack using careers : an ethnographic study in London [PDF]
Despite over two decades of crack use in the UK, there is little UK-focused research and little understanding of crack careers, the social context of crack use and health-related risks.
Briggs, Daniel
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Journal of Civil Engineering and Management, 2011 The paper presents method of calculation of eigenfrequencies of the cracked reinforced concrete beams including discreet model of crack. The described method is based on the stiff finite elements method.
Mieczysław Kaminski +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Numerical implementation of the eXtended Finite Element Method for dynamic crack analysis [PDF]
, 2008 A numerical implementation of the eXtended Finite Element Method (X-FEM) to analyze crack propagation in a structure under dynamic loading is presented in this paper.
Pantalé, Olivier +2 more
core +1 more source
Analisa Kegagalan pada Fuel Intake Manifold Pesawat Terbang Boeing 737-500
Jurnal Teknik ITS, 2013 Fuel intake manifold merupakan komponen yang sangat penting di pesawat terbang dimana fuel intake manifold berfungsi sebagai penyalur bahan bakar yang akan dibawa ke engine.
Jeffri Malau, Rochman Rochiem
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Development of strain gages to analyze the stress intensity factor of a crack tip
Nihon Kikai Gakkai ronbunshu, 2015 There are currently one or two kinds of strain gages to measure the stress intensity factor. It might not be sometimes easy to analyze the stress intensity factor with those gages.
Shigeru KUROSAKI +5 more
doaj +1 more source