Results 51 to 60 of about 783,269 (286)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Mode I crack tip fields: strain gradient plasticity theory versus J2 flow theory

, 2019
The mode I crack tip asymptotic response of a solid characterised by strain gradient plasticity is investigated. It is found that elastic strains dominate plastic strains near the crack tip, and thus the Cauchy stress and the strain state are given ...
Fleck, Norman A., Martínez-Pañeda, Emilio   +1 more
core   +1 more source

Slow crack growth : models and experiments [PDF]

, 2007
The properties of slow crack growth in brittle materials are analyzed both theoretically and experimentally. We propose a model based on a thermally activated rupture process.
Ciliberto, Sergio, Santucci, Stéphane, Vanel, Loic   +2 more
core   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

High-speed laser-directed energy deposition of crack-free wear-resistant and anti-corrosive Al/Cu bimetal components

Virtual and Physical Prototyping
Al/Cu bimetal components (BMCs) possess higher thermal conductivity, better wear resistance and corrosion resistance than Al and Al alloys. It is a big challenging task to fabricate a high-performance Al/Cu BMC by a conventional infrared (IR) laser ...
Junhao Sun, Zhuguo Li, Dongsheng Wu, Hisaya Komen, Manabu Tanaka, Joerg Volpp, Gang Luo, Yongkang Zhang, Ninshu Ma, Wei Jiao, Ke Feng   +10 more
doaj   +1 more source

Simulation of Near-Tip Crack Behaviour and Its Correlation to Fatigue Crack Growth with a Modified Strip-Yield Model [PDF]

, 2008
A modified strip-yield model has been developed to simulate the plasticity-induced crack closure under the constant amplitude (CA) and a single overload loading conditions.
Chen, Y.K., Tiu, W., Wang, L., Xu, Y.
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Microstructural modelling of creep crack growth from a blunted crack [PDF]

, 1998
The effect of crack tip blunting on the initial stages of creep crack growth is investigated by means of a planar microstructural model in which grains are represented discretely. The actual linking-up process of discrete microcracks with the macroscopic
Giessen, E. van der,, Onck, P.R.,
core  

Fatigue crack growth in thin notched woven glass composites under tensile loading. Part II: modelling [PDF]

, 2011
Fatigue propagation of a through-the-thickness crack in thin woven glass laminates is difficult to model when using homogeneous material assumption. Crack growth depends on both the fatigue behaviour of the fibres and of the matrix, these two phenomena ...
Barrau, Jean-Jacques, Bizeul, Matthieu, Bouvet, Christophe, Cuenca, Rémy   +3 more
core   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source