Results 91 to 100 of about 68,841 (302)

Near-threshold fatigue propagation of physically through-thickness short and long cracks in a low alloy steel [PDF]

open access: yes, 2014
International audienceIn this paper, the near-threshold fatigue behavior of physically through-thickness short cracks and of long cracks in a low alloy steel is investigated by experiments in ambient air. Physically through-thickness short fatigue cracks
Chretien, Gaëlle   +5 more
core   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Numerical Simulation of the Effect of Pre-Strain on Fatigue Crack Growth in AA2024-T351

open access: yesMetals
The objective here is to study the effect of pre-strain on fatigue crack growth (FCG) in 2024-T351 aluminum alloy. Three pre-strain conditions were considered: without pre-strain, compressive and tensile permanent pre-strains of 4%.
Diogo M. Neto   +3 more
doaj   +1 more source

In situ measurement of fatigue crack opening stresses by nonlinear vibro-acoustic modulation testing

open access: yesAdvances in Mechanical Engineering, 2017
The difficulty of accurately measuring crack closure regions has hindered measurements of opening or closure stresses, and ultrasonic methods have shown great potentialities in evaluating closure area. Many recent researches have confirmed the advantages
Jun Jia   +3 more
doaj   +1 more source

Fatigue crack closure and closure development in a high strength aluminium alloy [PDF]

open access: yes, 2015
A dissertation submitted to the Faculty of Engineering, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science in Engineering.
Garz, Reiner Ernst
core  

Some experimental observations of crack-tip mechanics with displacement data [PDF]

open access: yes, 2015
Estudio de la mecánica en el vértice de la grieta mediante datos de desplazamiento.In the past two decades, crack-tip mechanics has been increasingly studied with full-field techniques.
Lopez-Crespo, Pablo   +3 more
core   +4 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Environmental fatigue in aluminum-lithium alloys [PDF]

open access: yes
Aluminum-lithium alloys exhibit similar environmental fatigue crack growth characteristics compared to conventional 2000 series alloys and are more resistant to environmental fatigue compared to 7000 series alloys.
Piascik, Robert S.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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