Results 51 to 60 of about 68,841 (302)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Deformation and failure characteristics of weathered granite under uniaxial compression
AIP Advances, 2019 In this paper, we have examined the crack formation of weathered granite by monitoring acoustic emissions (AE) under uniaxial compression. Except for the uniaxial compressive strength (UCS), the thresholds have been determined for crack closure, crack ...
Lingfan Zhang +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
ON CRACK CLOSURE IN FATIGUE CRACK GROWTH
, 1978 A brief review of the various forms of closure is given, and the relative importance of plasticity-induced closure and roughness-induced closure is considered. On the basis of the lack of a thickness effect and an insensitivity to R in the absence of closure it is concluded that plasticity-induced closure plays a relatively minor role in affecting the ...
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Fatigue crack growth and crack closure in vacuum.
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1985 For S35C medium carbon steel and A5083-O aluminum alloy, fatigue crack growth tests were carried out in vacuum and in air under ΔK-increasing-decreasing condition, and crack growth rates and crack closure behavior were investigated in detail. In addition, ΔK constant tests were performed in air-to-vacuum-to-air environment.
m.jono, Song, JH Song, Ji Ho, m.ohgaki
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Effect of Interrupted Ageing and Retrogression-Reageing Treatments on Fatigue Crack Growth with a Single Applied Overload in 7050 Aluminum Alloy [PDF]
Materials Research, 2018 The influences of interrupted ageing and retrogression and re-ageing heat treatments on fatigue crack growth with a single applied overload in 7050 aluminum alloy were investigated.
André Luís Moreira de Carvalho +1 more
doaj +2 more sources
Key aspects in 3D fatigue crack closure numerical modelling [PDF]
, 2018 Since long time, fatigue crack closure has been studied by means of finite element models. Initially by bi-dimensional models and recently, due to the higher computational capabilities, the use of three-dimensional models has been extended, providing a
Camas, Daniel +2 more
core