Results 51 to 60 of about 68,665 (303)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Effects of Processing Residual Stresses on Fatigue Crack Growth Behavior of Structural Materials: Experimental Approaches and Microstructural Mechanisms [PDF]

, 2012
Fatigue crack growth mechanisms of long cracks through fields with low and high residual stresses were investigated for a common structural aluminum alloy, 6061-T61.
A.K. Vasudevan, Christopher J. Lammi, D.A. Lados, D.H. Lee, D.L Chen, Diana A. Lados, F. Bergner, J.C. Newman Jr, L.P. Borrego, L.P. Borrego, M. Beghini, P.C. Paris, R.H. Christensen, S.R. Daniewicz, W. Elber, Y.C. Lam   +15 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

ON CRACK CLOSURE IN FATIGUE CRACK GROWTH

, 1978
A brief review of the various forms of closure is given, and the relative importance of plasticity-induced closure and roughness-induced closure is considered. On the basis of the lack of a thickness effect and an insensitivity to R in the absence of closure it is concluded that plasticity-induced closure plays a relatively minor role in affecting the ...
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Effect of Interrupted Ageing and Retrogression-Reageing Treatments on Fatigue Crack Growth with a Single Applied Overload in 7050 Aluminum Alloy [PDF]

Materials Research, 2018
The influences of interrupted ageing and retrogression and re-ageing heat treatments on fatigue crack growth with a single applied overload in 7050 aluminum alloy were investigated.
André Luís Moreira de Carvalho, Juliana de Paula Martins   +1 more
doaj   +2 more sources

Fatigue crack growth and crack closure in vacuum.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1985
For S35C medium carbon steel and A5083-O aluminum alloy, fatigue crack growth tests were carried out in vacuum and in air under ΔK-increasing-decreasing condition, and crack growth rates and crack closure behavior were investigated in detail. In addition, ΔK constant tests were performed in air-to-vacuum-to-air environment.
m.jono, Song, JH Song, Ji Ho, m.ohgaki
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source