Results 51 to 60 of about 58,593 (304)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Environmentally-assisted Fatigue Crack Growth in AA7050-T73511 Al Alloy and AA2050-T84 Al-Cu-Li Alloy [PDF]
Materials Research, 2015 The aim of this study was to evaluate and compare the effect of low temperature and saline environment on the fatigue crack growth behavior of the AA7050-T7451 Al alloy and the recently developed AA2050-T Al-Cu-Li alloy.
Jéferson Aparecido Moreto +6 more
doaj +2 more sources
Crack closure and retardation effects – experiments and modelling
Procedia Structural Integrity, 2017 Abstract The design of cyclically loaded components is in many cases carried out on the basis of experiments on small-scale laboratory specimens. In this approach, many effects such as load ratio, residual stresses and short crack growth are taken into account and described in a computational crack growth model.
J. Maierhofer, H.-P. Gänser, R. Pippan
openaire +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Numerical Simulation of the Effect of Pre-Strain on Fatigue Crack Growth in AA2024-T351
MetalsThe objective here is to study the effect of pre-strain on fatigue crack growth (FCG) in 2024-T351 aluminum alloy. Three pre-strain conditions were considered: without pre-strain, compressive and tensile permanent pre-strains of 4%.
Diogo M. Neto +3 more
doaj +1 more source
A Numerical Study of the Effect of Isotropic Hardening Parameters on Mode I Fatigue Crack Growth
Metals, 2020 The consideration of plastic crack tip opening displacement (CTOD, δp), as a crack driving force has given us the opportunity to predict fatigue crack growth (FCG) rate numerically, and, therefore, to develop parametric studies focused on the effect
M. F. Borges +3 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
An Integral Formulation of Two-Parameter Fatigue Crack Growth Model
Advances in Materials Science and Engineering, 2018 A two-parameter fatigue crack growth algorithm in integral form is proposed, which can describe the continuous crack growth process over the time period.
Jianguo Wu +3 more
doaj +1 more source
A numerical analysis of the plastic wake influence on plasticity induced crack closure [PDF]
, 2017 Fatigue crack closure has been studied by means of finite element method since long time ago. Most work has been performed considering bi-dimensional models. Lately, the use of threedimensional models has been extended.
Antunes, F.V. +3 more
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