Results 51 to 60 of about 3,307 (180)

Crack closure and retardation effects – experiments and modelling

Procedia Structural Integrity, 2017
Abstract The design of cyclically loaded components is in many cases carried out on the basis of experiments on small-scale laboratory specimens. In this approach, many effects such as load ratio, residual stresses and short crack growth are taken into account and described in a computational crack growth model.
J. Maierhofer, H.-P. Gänser, R. Pippan
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Environmentally-assisted Fatigue Crack Growth in AA7050-T73511 Al Alloy and AA2050-T84 Al-Cu-Li Alloy [PDF]

Materials Research, 2015
The aim of this study was to evaluate and compare the effect of low temperature and saline environment on the fatigue crack growth behavior of the AA7050-T7451 Al alloy and the recently developed AA2050-T Al-Cu-Li alloy.
Jéferson Aparecido Moreto, Fernando Antônio Paschoal Júnior, Carla Isabel Santos Maciel, Luis Henrique Camargo Bonazzi, José Francisco Leonelli Júnior, Cassius Olívio Figueiredo Terra Ruchert, Waldek Wladimir Bose Filho   +6 more
doaj   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Numerical Simulation of the Effect of Pre-Strain on Fatigue Crack Growth in AA2024-T351

Metals
The objective here is to study the effect of pre-strain on fatigue crack growth (FCG) in 2024-T351 aluminum alloy. Three pre-strain conditions were considered: without pre-strain, compressive and tensile permanent pre-strains of 4%.
Diogo M. Neto, Edmundo Sérgio, André Agra, Fernando V. Antunes   +3 more
doaj   +1 more source

A Numerical Study of the Effect of Isotropic Hardening Parameters on Mode I Fatigue Crack Growth

Metals, 2020
The consideration of plastic crack tip opening displacement (CTOD, δp), as a crack driving force has given us the opportunity to predict fatigue crack growth (FCG) rate numerically, and, therefore, to develop parametric studies focused on the effect
M. F. Borges, F. V. Antunes, P. A. Prates, R. Branco   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An Integral Formulation of Two-Parameter Fatigue Crack Growth Model

Advances in Materials Science and Engineering, 2018
A two-parameter fatigue crack growth algorithm in integral form is proposed, which can describe the continuous crack growth process over the time period.
Jianguo Wu, Shan Jiang, Wei Zhang, Zili Wang   +3 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source