Results 41 to 50 of about 7,508,587 (309)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Some practical crack path examples [PDF]
Fracture and Structural Integrity, 2007 It is well known that many engineering structures and components, as well as consumer items, contain cracks or crack-like flaws. It is widely recognised that crack growth must be considered both in designand in the analysis of failures.
Les P. Pook
doaj
On the theoretical modeling of fatigue crack growth
Journal of the mechanics and physics of solids, 2018 Although fatigue is by far the most common mode of failure of structural materials, mechanistic understanding is still lacking. For example, the fundamental Paris law which relates the crack growth rate to stress-intensity factor range is still ...
Z. Hosseini +4 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Thresholds of time dependent intergranular crack growth in a nickel disc alloy Alloy 720Li
MATEC Web of Conferences, 2014 At high temperatures in air, introducing a dwell period at the peak stress of fatigue cycles promotes time dependent intergranular crack growth which can increase crack growth rates by upto a few orders of magnitude from the rates of transgranular ...
Li Hangyue +4 more
doaj +1 more source
A Surrogate Approach to Reveal Microstructural Mechanisms Controlling the 3D Short Crack Growth in a Ti-6Al-4V Alloy [PDF]
MATEC Web of Conferences, 2020 Microstructural features and short crack growth behavior were characterized and linked in a Ti-6Al-4V by employing X-ray micro-tomography combined with EBSD serial sectioning.
Hassanipour Meysam +6 more
doaj +1 more source
A microstructure-sensitive driving force for crack growth
Journal of the mechanics and physics of solids, 2018 A stored energy based methodology for calculating the driving force for crack growth is introduced which can capture the highly local microstructural sensitivity.
David J. Wilson, Zebang Zheng, F. Dunne
semanticscholar +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Actuators, 2023 Acoustic emission (AE) was monitored during stress intensity factor (SIF)-controlled high-cycle fatigue (HCF) tests on an aluminum 2024-T3 specimen with a fatigue crack growing at its center.
Roshan Joseph, Victor Giurgiutiu
doaj +1 more source
ON CRACK CLOSURE IN FATIGUE CRACK GROWTH
, 1978 A brief review of the various forms of closure is given, and the relative importance of plasticity-induced closure and roughness-induced closure is considered. On the basis of the lack of a thickness effect and an insensitivity to R in the absence of closure it is concluded that plasticity-induced closure plays a relatively minor role in affecting the ...
openaire +2 more sources