Results 41 to 50 of about 69,564 (313)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Predicting fatigue crack growth rate in a welded butt joint: The role of effective R ratio in accounting for residual stress effect [PDF]

, 2009
A simple and efficient method is presented in this paper for predicting fatigue crack growth rate in welded butt joints. Three well-known empirical crack growth laws are employed using the material constants that were obtained from the base material ...
Servetti, Guido, Zhang, X.
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Microstructural modelling of creep crack growth from a blunted crack [PDF]

, 1998
The effect of crack tip blunting on the initial stages of creep crack growth is investigated by means of a planar microstructural model in which grains are represented discretely. The actual linking-up process of discrete microcracks with the macroscopic
Giessen, E. van der, Onck, P.R.,, Onck, P.R., Giessen, E. van der; id_orcid, Giessen, E. van der,   +4 more
core  

Fatigue crack growth in thin notched woven glass composites under tensile loading. Part I: experimental [PDF]

, 2011
Helicopter blades are made of composite materials mainly loaded in fatigue and have normally relatively thin skins. A through-the-thickness crack could appear in these skins.
Barrau, Jean-Jacques, Bizeul, Matthieu, Bouvet, Christophe, R. Cuenca, J.J. Barrau, Cuenca, Rémy, M. Bizeul, C. Bouvet   +7 more
core   +1 more source

Improved computation method in residual life estimation of structural components [PDF]

Theoretical and Applied Mechanics, 2013
This work considers the numerical computation methods and procedures for the fatigue crack growth predicting of cracked notched structural components.
Maksimović Stevan M., Maksimović Katarina S.   +1 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Surface Crack Shape Evolution Modelling using an RMS SIF approach [PDF]

, 2010
The majority of fatigue cracks in thick plate and tubular sections in structural components are two-dimensional surface cracks having significant propagation lives before becoming critical.
Han, S. K., Brennan, Feargal P., Chahardehi, Amir Ebrahim   +2 more
core   +1 more source

Thresholds of time dependent intergranular crack growth in a nickel disc alloy Alloy 720Li

MATEC Web of Conferences, 2014
At high temperatures in air, introducing a dwell period at the peak stress of fatigue cycles promotes time dependent intergranular crack growth which can increase crack growth rates by upto a few orders of magnitude from the rates of transgranular ...
Li Hangyue, Fisk Joe, Lim Lik-Beng, Williams Steve, Bowen Paul   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source