Results 61 to 70 of about 5,163,287 (193)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Influence of grain structure and slip planarity on fatigue crack growth in low alloying artificially aged 2xxx aluminium alloys [PDF]
, 2007 The fatigue crack growth behaviour under constant amplitude loading of three low alloying artificially aged 2xxx aluminium alloys with distinct microstructures is analysed. Fatigue crack growth tests show a correlation between fatigue performance and the
Starink, M.J. +3 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Influence of corrosion and creep on intergranular fatigue crack path in 2XXX aluminium alloys [PDF]
, 2010 In this paper, two examples of the influence of time-dependent processes on crack path in two 2XXX aluminium alloys are presented. The first example is concerned with corrosion–fatigue crack growth resistance of a 2024 T351 alloy cracked in the S–L ...
Odemer, Grégory +2 more
core +1 more source
STATISTICAL ANALYSIS OF FATIGUE CRACK GROWTH TEST DATA FOR 2024-T62 ALUMINUM ALLOY
Jixie qiangdu, 2019 The fatigue crack growth tests for 2024-T62 aluminum alloy were conducted under three stress levels, the dispersion of fatigue crack growth were analyzed by using experimental data based on mathematical statistics.
WANG XuHu +3 more
doaj
Metals, 2020 In this paper, the interactions between double cracks with a co-bisector-line were investigated theoretically and experimentally. Fatigue crack growth tests of specimens with a single crack or double cracks were carried out to measure the crack growth ...
Zhichao Han, Caifu Qian, Huifang Li
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A numerical study of crack shielding and deflection under extensive plasticity [PDF]
, 2009 Experimentally observed crack deflection events in multi-layered material systems, occurring even under pure mode-I loading, are here simulated and explained through elasto-plastic finite element modelling.
Reed, Philippa A.S. +2 more
core +1 more source
Nihon Kikai Gakkai ronbunshu, 2018 Structural integrity of cracked pipes is assessed by predicting crack growth. In the fitness-for-service code of the Japan Society of Mechanical Engineers (JSME), the crack growth is predicted using stress intensity factor at the deepest and surface ...
Masayuki KAMAYA
doaj +1 more source