Results 51 to 60 of about 5,163,287 (193)

Numerical Simulation on Crack–Inclusion Interaction for Rib-to-Deck Welded Joints in Orthotropic Steel Deck

open access: yesMetals, 2023
Weld defects such as porosity, inclusion, burn-through, and lack of penetration are difficult to detect and control effectively in an orthotropic steel deck (OSD), which will be a fatigue crack initiation site and lead to several fatigue cracking.
Yuan Luo   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

An inverse method for evaluating weld residual stresses via fatigue crack growth test data [PDF]

open access: yes, 2010
This paper presents an inverse method for calculating the thermal residual stresses in welded specimens via measured fatigue crack growth rates. Firstly, fracture-mechanics superposition law has been used to extract the stress intensity factor due to ...
Rui Bao   +3 more
core   +1 more source

Crack-Configuration Analysis of Metal Conductive Track Embedded in Stretchable Elastomer

open access: yesMicromachines, 2018
This paper reports the analysis of the crack configuration of a stretched metal conductive track that is embedded in a stretchable elastomer. The factor determining the crack configurations is analyzed by modeling as well as experiments.
Tomoya Koshi, Eiji Iwase
doaj   +1 more source

Non-Crack-Growth Acoustic Emission Observed in Controlled-Stress-Intensity-Factor High-Cycle-Fatigue Tests

open access: yesActuators, 2023
Acoustic emission (AE) was monitored during stress intensity factor (SIF)-controlled high-cycle fatigue (HCF) tests on an aluminum 2024-T3 specimen with a fatigue crack growing at its center.
Roshan Joseph, Victor Giurgiutiu
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Influence of woven ply degradation on fatigue crack growth in thin notched composites under tensile loading [PDF]

open access: yes, 2010
This paper deals with the fatigue of the through the-thickness crack propagation in thin notched composite laminates made of two glass woven plies. It highlights the different crack growths between warp and weft directions of the woven ply.
Barrau, Jean-Jacques   +3 more
core   +1 more source

R-curve Evaluation of Copper and Nickel Single Crystals Using Atomistic Simulations

open access: yesCrystals, 2018
The technique of molecular statics (MS) simulation was employed to determine the crack growth resistance curve of Cu and Ni single crystals. Copper and Ni single crystal nanoplates with an edge crack subjected to a tensile displacement were simulated ...
Xiao Ru Zhuo   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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