Results 91 to 100 of about 1,411,543 (350)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
MetalsThe role of notch stress and surface defects on fatigue crack initiation and small-crack propagation behavior has been investigated using groove simulation specimens.
Zuopeng Zhao, Xuteng Hu, Zhiwei Guo
doaj +1 more source
Prediction of fatigue crack-growth patterns and lives in three-dimensional cracked bodies [PDF]
Fatigue crack growth patterns and lives for surface cracks, surface cracks at holes, and corner cracks at holes in three dimensional bodies were predicted using linear-elastic fracture mechanics concepts that were modified to account for crack-closure ...
Newman, J. C., Jr., Raju, I. S.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
EXPERIMENT STUDY ON CRACK GROWTH RATE OF ADB610 STEEL UNDER DIFFERENT STRESS RATIOS
Jixie qiangdu, 2016 The test of the fatigue crack growth rate under five stress ratios（ R = 0. 1,0. 2,0. 3,0. 4 and 0. 5） is completed used the compact tensile specimen. The test data are processed by using incremental polynomial method and the expressions and curves of ...
WEI Long +3 more
doaj
Investigation of the Combined Influence of Temperature and Humidity on Fatigue Crack Growth Rate in Al6082 Alloy in a Coastal Environment. [PDF]
Materials (Basel), 2023 Alqahtani I, Starr A, Khan M.
europepmc +1 more source
Fatigue crack propagation behaviour in wire+arc additive manufactured Ti‐6Al‐4V: Effects of microstructure and residual stress [PDF]
, 2016 Fatigue crack propagation tests of Ti‐6Al‐4V fabricated by the Wire+Arc Additive Manufacturing (WAAM) process are analysed. Crack growth rate and trajectory are examined before and after the crack tip crossing an interface between the WAAM and wrought ...
ABAQUS 6.13 +40 more
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Fatigue Crack Growth Rate Description of RF-Plasma-Sprayed Refractory Metals and Alloys. [PDF]
Materials (Basel), 2023 Kovarik O, Cizek J, Klecka J.
europepmc +1 more source
Interlaminar crack growth in fiber reinforced composites during fatigue, part 3 [PDF]
Interlaminar crack growth behavior in fiber-reinforced composites subjected to fatigue loading was investigated experimentally and theoretically. In the experimental phase, inter-laminar crack propagation rates and mechanisms were determined for the ...
Wang, H. T., Wang, S. S.
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