Results 71 to 80 of about 230,446 (308)

A Modified Loading Method for Separating the Effect of Residual Stress on Fatigue Crack Growth Rate of Welded Joints [PDF]

, 2017
A novel loading method is proposed to remove the effect of residual stress on measured fatigue crack growth rate in welded joint, using which the influence of empirical crack growth rate correlation equations on the results can be avoided.
Bao, Rui, Liu, Hao, Xu, Yaowu, Zhang, Xiang   +3 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Observation of the initial process of internal fracture in very high cycle fatigue in Ti-6Al-4V by synchrotron radiation μCT imaging

Nihon Kikai Gakkai ronbunshu, 2017
The initiation and growth of internal small fatigue cracks with around ten or several dozen μm in Ti-6Al-4V were nondestructively examined by using synchrotron radiation μCT at the large synchrotron radiation facility SPring-8.
Fumiyoshi YOSHINAKA, Takashi NAKAMURA, Kazuaki TAKAKU, Daiki SHIOZAWA, Yoshikazu NAKAI, Kentaro UESUGI   +5 more
doaj   +1 more source

Assessment of crack growth development in main pipeline on the basis of elastoplastic model [PDF]

Омский научный вестник, 2019
A method for predicting the growth of surface cracks in the wall of the main pipeline under action of operational loads is proposed. The elastoplastic model of surface crack growth under biaxial loading is described on the example of steel 20.
К. А. Vansovich, I. P. Aistov, А. А. Nakhlestkin, D. S. Beseliya   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Small fatigue crack growth behavior of TB6 titanium alloy

Cailiao gongcheng, 2019
The growth behavior of naturally-initiated small cracks in single edge notched tensile (SENT) specimen of TB6 titanium alloy was studied. Fatigue experiments were conducted under constant amplitude loading with the stress ratios R of 0.1 and 0.5 at room ...
XU Liang, HUANG Shuang-jun, HUI Li, WANG Lei, ZHOU Song, ZHAO Qing   +5 more
doaj   +1 more source

Evolution of anodic stress corrosion cracking in a coated material [PDF]

, 2010
In the present paper, we investigate the influence of corrosion driving forces and interfacial toughness for a coated material subjected to mechanical loading. If the protective coating is cracked, the substrate material may become exposed to a corrosive
Bjerkén, C., Ortiz, M.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

EXPERIMENTAL STUDY ON CRACK GROWTH RATE OF B780CF STEEL WELDED JOINTS UNDER DIFFERENT WELDING PROCESS

Jixie qiangdu, 2018
The fatigue crack growth rate under different welding process was tested with standard compact tension specimen,the test data are processed by using incremental polynomial method and the crack growth rate curve under different welding process was ...
SHENG ShouYong, WANG ShiYue, LIU GuoShou, ZHENG YiHua   +3 more
doaj