Results 51 to 60 of about 4,014,681 (349)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FREE VIBRATION ANALYSIS OF A SIMPLY SUPPORTED BEAM WITH A VERTICAL EMBEDDED CRACK
Jixie qiangdu, 2016 Local stiffness and performances of a beam structure will be changed by a crack,which causes changes in mode parameters. Focused on this problem,a simply supported beam is studied based on finite element method.
SONG XiaoHua, LIU Jing
doaj
Vibration, 2022 The crack-induced changes in the vertical transient response of a rotating shaft–disc system, Jeffcott rotor, are investigated for transverse crack detection. The crack is considered as a breathing crack.
Hamid Khorrami +2 more
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
A unique fracture in fatigue of age-hardened Al alloys and its macro and microscopic aspects
Nihon Kikai Gakkai ronbunshu, 2017 There are many studies reported that a fatigue crack propagated in a tensile mode macroscopically and the fracture surface was mainly occupied by striations in many metals.
Norio KAWAGOISHI +4 more
doaj +1 more source
Vietnam Journal of Mechanics, 2020 The problem of using the modal curvature for crack detection is discussed in this paper based on an exact expression of mode shape and its curvature.
Nguyen Tien Khiem
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Growth mechanism of a fatigue crack of extruded high strength Al alloy 7075-T6 in high humidity
Nihon Kikai Gakkai ronbunshu, 2015 Effect of humidity on the growth mechanism of a fatigue crack in an age-hardened Al alloy was investigated in relative humidity environments of 25% and 85% at loading frequencies of 50Hz and 6Hz.
Norio KAWAGOISHI +5 more
doaj +1 more source
Application of local and non-local approaches to multiple fatigue crack initiation and propagation [PDF]
, 2003 Fatigue strength conditions presented in terms of normalized equivalent stress functionals defined on loading processes are used to unite the stages of material damage with fatigue crack initiation and multiple crack propagation under arbitrary loading ...
Mikhailov, SE, Namestnikova, IV
core