Results 31 to 40 of about 8,141 (305)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A numerical study of non-linear crack tip parameters [PDF]

Fracture and Structural Integrity, 2015
Crack closure concept has been widely used to explain different issues of fatigue crack propagation. However, different authors have questioned the relevance of crack closure and have proposed alternative concepts.
F.V. Antunes, R. Branco, L. Correia, AL Ramalho   +3 more
doaj   +3 more sources

Determining mode I cohesive law of Pinus pinaster by coupling double cantilever beam test with digital image correlation [PDF]

Fracture and Structural Integrity, 2015
The direct identification of the cohesive law in pure mode I of Pinus pinaster is addressed. The approach couples the double cantilever beam (DCB) test with digital image correlation (DIC).
J. Xavier, M. Oliveira , J.J.L. Morais , M.F.S.F. de Moura   +3 more
doaj   +1 more source

Does the cyclic J-integral ΔJ describe the crack-tip opening displacement in the presence of crack closure?

, 2015
In this paper, the correlation of the cyclic J-integral, ΔJ, and the cyclic crack-tip opening displacement, ΔCTOD, is studied in the presence of crack closure to assess the question if ΔJ describes the crack-tip opening displacement in this case. To this
Metzger, M., Schweizer, C., Metzger, Mario, Seifert, Thomas, Seifert, T., Schweizer, Christoph   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Displacement Discontinuity Analysis of the Effects of Various Hydraulic Fracturing Parameters on the Crack Opening Displacement (COD) [PDF]

Journal of Petroleum Science and Technology, 2018
The combination of horizontal drilling along with hydraulic fracturing has significantly improved the production of hydrocarbon reservoirs and made it possible to extract the relatively impermeable and uneconomical reservoirs.
Abolfazl Moradi, Behzad Tokhmechi, Vamegh Rasolui, Mohammad Fatehi Marji   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source