Results 31 to 40 of about 1,306,615 (288)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Size effects on residual stress and fatigue crack growth in friction stir welded 2195-T8 aluminium - Part I: Experiments [PDF]
, 2011 Residual stress fields were measured in three different sizes of Compact-Tension (C(T)) and eccentrically loaded single edge notch (ESE(T)) specimens containing transverse or longitudinal welds. The effect of size on residual stress profiles was studied.
Irving, Phil E. +7 more
core +1 more source
Crack tip strain evolution and crack closure during overload of a growing fatigue crack [PDF]
Fracture and Structural Integrity, 2017 It is generally accepted that fatigue crack growth is retarded after an overload, which has been explained either by plasticity-induced crack closure or near-tip residual stress.
De-Qiang Wang +3 more
doaj +3 more sources
Open Engineering, 2022 This article presents the results of analytical and numerical research focused on the numerical determination of selected fracture mechanics parameters for beams containing a crack in the state of four-point bending with the dominance of a plane strain ...
Graba Marcin
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A numerical study of non-linear crack tip parameters [PDF]
Fracture and Structural Integrity, 2015 Crack closure concept has been widely used to explain different issues of fatigue crack propagation. However, different authors have questioned the relevance of crack closure and have proposed alternative concepts.
F.V. Antunes +3 more
doaj +3 more sources
Jixie qiangdu, 2015 In this article,elastic-plastic curved crack tip opening displacement in hardened material under quasi-static loads has been mainly studied,and curved crack tip opening displacement has been calculated as a practical application of a second order ...
YANG DaPeng +4 more
doaj
AlloysUsing the results from testing industrial batches of 23 mm steel heavy plates after thermomechanical rolling and subsequent post-weld heat treatment, the patterns of fatigue crack formation in the fracture specimens during CTOD (Crack Tip Opening ...
Eugene Goli-Oglu +2 more
doaj +1 more source
Displacement Discontinuity Analysis of the Effects of Various Hydraulic Fracturing Parameters on the Crack Opening Displacement (COD) [PDF]
Journal of Petroleum Science and Technology, 2018 The combination of horizontal drilling along with hydraulic fracturing has significantly improved the production of hydrocarbon reservoirs and made it possible to extract the relatively impermeable and uneconomical reservoirs.
Abolfazl Moradi +3 more
doaj +1 more source