Results 51 to 60 of about 8,141 (305)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Quantifying nonlinear fracture parameters in bituminous SCB specimens: A compliance-based approach

Case Studies in Construction Materials
Bituminous mixtures containing various defects, such as cracks and voids, exhibit ductile behavior in hot environments and brittle behavior in cold environments.
Ragip Ince, Erkut Yalcin, Mehmet Yilmaz
doaj   +1 more source

Computation of the crack opening displacements for Vickers indentation cracks

, 2002
Vickers indentation cracks are an appropriate tool to determine the crack-tip toughness K I 0 and possibly the bridging relation of ceramics with an R-curve behaviour from the total crack opening displacements. Two contributions to the total crack opening displacement field are addressed.
openaire   +2 more sources

Numerical Technique for Surface Opening Displacement of an External Crack in an Infinite Elastic Space

, 2011
This paper presents a numerical technique for determination of surface opening displacements of an external circular crack embedded in an infinite elastic space.
K. Kiattikomol, Chaiyat, S., S. Chaiyat, Kiattikomol, K.   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Determination of fracture parameters for interface cracks in transverse isotropic magnetoelectroelastic composites

Curved and Layered Structures, 2015
To determine fracture parameters of interfacial cracks in transverse isotropic magnetoelectroelastic composites, a displacement extrapolation formula was derived.
Lei Jun, Sun Pengbo, Bui Tinh Quoc
doaj   +1 more source

In-Situ Estimation of Surface Crack Shape From Crack Opening Displacement by Use of NCOD Database System

, 2010
This paper proposes an in-situ estimation of crack shape from crack opening displacement (COD) by using of a visualized database system consisting of numerical calculation data of normalized crack opening displacement (NCOD) for some kinds of crack types.
Zheng He, Weiguo Wu, Jingxia Yue, Yukio Fujimoto   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Two paramether description of crack opening displacement

, 2002
The basic aim of this paper is to describe the influence of T-stress on a crack profile, crack tip opening displacement CTOD and crack mouth opening displacement CMOD. Different methods of determination CTOD values are discussed.
Hutař, Pavel
core