Results 51 to 60 of about 67,249 (303)
Performance of perforated FRP stub beams subject to static transverse actions [PDF]
, 2020 This paper presents an experimental programme designed to investigate the failure mode and ultimate capacity of pultruded glass fibre reinforced polymer (GFRP) cellular profiles subject to transverse loading.
Gand, Alfred +2 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Experimental study on fracture behavior of pre-notched mortar beams using ESPI technique [PDF]
, 2011 Electronic Speckle Pattern Interferometry (ESPI) technique is of high sensitivity and can provide full-field surface deformation. This paper introduces the application of ESPI technique to measure the surface deformation of pre-notched mortar beams in ...
Chen, H, Su, RKL
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Curved and Layered Structures, 2015 To determine fracture parameters of interfacial cracks in transverse isotropic magnetoelectroelastic composites, a displacement extrapolation formula was derived.
Lei Jun, Sun Pengbo, Bui Tinh Quoc
doaj +1 more source
A new test methodology based on structural resonance for mode I fatigue delamination growth in an unidirectional composite [PDF]
, 2013 A specific device has been set up to test by vibration resonance the mode I fatigue delamination growth onset of composite laminates. This test system, based on the DCB test specimen, is a mass-spring-specimen dynamic system designed to resonate.
Fressinet, Mathieu +4 more
core +4 more sources
Plasticity and the crack opening displacement in shells [PDF]
International Journal of Fracture Mechanics, 1972 The plastic deformations and the crack opening displacement, δ, in cylindrical shells with an axial or circumferential crack and spherical shells with a meridional crack are considered. It is assumed that outside the perturbation zone of the crack the shell is subjected to uniform membrane loads perpendicular to the crack.
F. Erdogan, M. Ratwani
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Quantifying nonlinear fracture parameters in bituminous SCB specimens: A compliance-based approach
Case Studies in Construction MaterialsBituminous mixtures containing various defects, such as cracks and voids, exhibit ductile behavior in hot environments and brittle behavior in cold environments.
Ragip Ince, Erkut Yalcin, Mehmet Yilmaz
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source