Results 71 to 80 of about 1,306,615 (288)

Plasticity and the crack opening displacement in shells [PDF]

, 1970
Plastic deformation and crack opening displacement in thin walled, cylindrical ...
Erdogan, F., Ratwani, M.
core  

Why is the modified wedge-opening-loaded test inadequate for characterizing gaseous hydrogen embrittlement in pipeline steels? A review

Corrosion Reviews
International hydrogen pipeline code ASME B31.12 requires the measurement of hydrogen affected fracture toughness using constant load or displacement tests standardized in ASTM E1681. The modified wedge-opening-loaded (WOL) specimen is loaded with a bolt
Kappes Mariano A., Palmerio Diego, Guerrina Jorge, Pérez Teresa E.   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Three-dimensional crack growth in multi-layered architectures for automotive plain bearings

, 2009
The assessment of shielding and anti-shielding effects on crack growth in multi-layered architectures is achieved using elasto-plastic finite element models.
Burke-Veliz, A., Reed, P.A.S., Syngellakis, S.   +2 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Measurement of Crack Tip Opening Displacement of Paper Using CCD Camera

, 1999
Crack opening displacement (COD) on a deep double notched tension specimen was quantitatively analyzed and showed a linear relationship between COD and the distance from the crack tip all through the testing period.
Tanaka, Atsushi; id_orcid, Yamauchi, Tatsuo   +1 more
core   +2 more sources

Determination of fracture mechanics parameters by digital image correlation method of surface crack for 7075 Al alloy under nonproportional cyclic loading (Growth life prediction method considering shear stress on the crack surface)

Nihon Kikai Gakkai ronbunshu
A method for predicting the propagation life of a crack initiated on the surface of a 7075 aluminum alloy under nonproportional loading was proposed using the modified Paris law.
Yuichi ONO, Kaito WATANABE, Nao KANEKO
doaj   +1 more source