Results 61 to 70 of about 8,141 (305)

Crack opening displacement and the associated response of laminates with varying constraints

, 1999
This paper reports an experimental study of the opening displacement behavior of 90-ply cracks in a class of composite laminates where the constraint to cracking is varied systematically.
Talreja, Ramesh,, Akshantala, Nagendra V.,, Varna, Janis,   +2 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Fracture properties of dolomite and prediction of fracture toughness based on BP-ANN

Scientific Reports
In this study, based on the digital image correlation technique, three-point bending tests were conducted on dolomite semi-circular bending (SCB) specimens, and the fracture properties of the SCB specimens, including crack opening displacement, apparent ...
Yu Guo, Dengkai Liu, Junying Rao, Feifei Guo, Yao Peng   +4 more
doaj   +1 more source

Comparison of the crack pattern in accelerated corrosion tests and in finite elements simulations

, 2010
In this work, the crack pattern obtained in accelerated corrosion tests is compared to the one obtained in numerical simulations for reinforced steel concrete samples.
Sanz Merino, Beatriz, Planas Rosselló, Jaime, Sancho Aznal, José María   +2 more
core  

Critical Crack Tip Opening Displacement for X70 and X80 Steels - A Parametric Study

, 2017
High strength line-pipe steels are widely used in long distance gas pipelines. Fracture toughness is one major parameter in the performance evaluation of these line-pipe steels. For high strength line-pipe steels, critical crack tip opening displacement (
Xiao Ben Liu, Bao Dong Wang, Qing Quan Duan, Hong Zhang   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Three-dimensional crack growth in multi-layered architectures for automotive plain bearings

, 2009
The assessment of shielding and anti-shielding effects on crack growth in multi-layered architectures is achieved using elasto-plastic finite element models.
Burke-Veliz, A., Reed, P.A.S., Syngellakis, S.   +2 more
core  

Correlation between long and short crack R-curves in alumina using the crack opening displacement and fracture mechanical weight function approach

, 1996
Both fine grain sized and coarse grain sized alumina has been used as a model material to correlate short crack R-curves by the surface-flaw-in-flexure method with long crack R-curves from a compact tension specimen.
Seidel, Jürgen, Theo Fett, Jurgen Seidel, Jurgen Rodel, Munz, D., Rödel, Jürgen, Martin Stech, Stech, Martin, Dietrich Munz, Fett, Theo   +9 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source