Results 61 to 70 of about 1,306,615 (288)

Quantifying nonlinear fracture parameters in bituminous SCB specimens: A compliance-based approach

Case Studies in Construction Materials
Bituminous mixtures containing various defects, such as cracks and voids, exhibit ductile behavior in hot environments and brittle behavior in cold environments.
Ragip Ince, Erkut Yalcin, Mehmet Yilmaz
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Does the cyclic J-integral ΔJ describe the crack-tip opening displacement in the presence of crack closure?

, 2015
In this paper, the correlation of the cyclic J-integral, ΔJ, and the cyclic crack-tip opening displacement, ΔCTOD, is studied in the presence of crack closure to assess the question if ΔJ describes the crack-tip opening displacement in this case. To this
Metzger, M., Schweizer, C., Metzger, Mario, Seifert, Thomas, Seifert, T., Schweizer, Christoph   +5 more
core   +1 more source

Interfacial crack analysis in layered media using couple-stress elasticity and the displacement discontinuity method

Tạp chí Khoa học và Công nghệ
Interfacial cracks between dissimilar materials represent a critical failure mechanism in layered structural systems such as coatings, composite laminates, and micro-structured materials. However, classical elasticity theory cannot adequately capture the
Sok An Yin, Jintara Lawongkerd
doaj   +1 more source

Determination of fracture parameters for interface cracks in transverse isotropic magnetoelectroelastic composites

Curved and Layered Structures, 2015
To determine fracture parameters of interfacial cracks in transverse isotropic magnetoelectroelastic composites, a displacement extrapolation formula was derived.
Lei Jun, Sun Pengbo, Bui Tinh Quoc
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Fracture properties of dolomite and prediction of fracture toughness based on BP-ANN

Scientific Reports
In this study, based on the digital image correlation technique, three-point bending tests were conducted on dolomite semi-circular bending (SCB) specimens, and the fracture properties of the SCB specimens, including crack opening displacement, apparent ...
Yu Guo, Dengkai Liu, Junying Rao, Feifei Guo, Yao Peng   +4 more
doaj   +1 more source

Study of monitoring model of crack opening displacement for high-pile wharf

Shuili Shuiyun Gongcheng Xuebao, 2017
Safety monitoring is an important measure for the safe operation of water conservancy projects. The monitoring model plays an important role in monitoring data analysis, and is widely used in the safety monitoring of reservoirs and dams.
CHEN Xudong, LI Junjie, HUO Zhongyan
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source