Results 51 to 60 of about 71,141 (311)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Evaluation of Fatigue Crack Growh Resistance of Rubber-Silica Composites and Analysis of the Role of Filler-Filler Interaction and Interface Bonding [PDF]

علوم و تکنولوژی پلیمر, 2019
Hypothesis: Fatigue crack growth (FCG) of rubber composites as controlled by the viscoelastic losses, is strongly dependent on the polymer-filler interfacial phenomena.
Mohammad Alimardani, Mehdi Razzaghi-Kashani   +1 more
doaj   +1 more source

Sex differences in HIV effects on visual memory among substance-dependent individuals [PDF]

, 2016
HIV’s effects on episodic memory have not been compared systematically between male and female substance-dependent individuals. We administered the Brief Visuospatial Memory Test–Revised (BVMT–R) to 280 substance-dependent HIV+ and HIV– men and women ...
Gonzalez, Raul, Keutmann, Michael K., Maki, Pauline M., Martin, Eileen M., Rubin, Leah H., Vassileva, Jasmin   +5 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Study on the Feasibility of Natural Frequency-Based Crack Detection

Applied Sciences
Owing to the long-standing statement that natural frequency-based crack detection is not sensitive enough to localised damage to identify small cracks, many natural frequency-based crack detection methods are validated by detecting cracks of moderate ...
Xutao Sun, Sinniah Ilanko, Yusuke Mochida, Rachael C. Tighe   +3 more
doaj   +1 more source

Damage quantification techniques in acoustic emission monitoring [PDF]

, 2011
Acoustic emission (AE) analysis is one of the several diagnostic techniques available nowadays for structural health monitoring (SHM) of engineering structures.
Chan, Tommy H.T., Kaphle, Manindra R., Tan, Andy, Thambiratnam, David   +3 more
core   +1 more source

Lamb wave near field enhancements for surface breaking defects in plates [PDF]

, 2012
Near field surface wave ultrasonic enhancements have previously been used to detect surface breaking defects in thick samples using Rayleigh waves. Here, we present analogous surface wave enhancements for Lamb waves propagating in plates.
Clough, A. R., Edwards, R. S. (Rachel S.)   +1 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

DAEENet: A novel Dual Attention based Edge Enhanced network for asphalt pavement deterioration detection and segmentation

Case Studies in Construction Materials
Accurate identification of asphalt pavement deterioration is essential for ensuring road safety and optimizing infrastructure maintenance. Traditional methods for detecting pavement distress are often inefficient, time-consuming, labor-intensive, and ...
Andrew Abraham P., Jefferey Joshua Thomas J., Hemanth K., Vasugi K., Sanjeev Kumar, Aravindkumar Sekar   +5 more
doaj   +1 more source

Study on Micro-Crack Induced Precision Severing of Quartz Glass Chips [PDF]

Micromachines, 2018
It is difficult to cut hard and brittle quartz glass chips. Hence, a method involving micro-crack-induced severing along a non-crack microgroove-apex by controlling the loading rate is proposed. The objective is to realize the rapid and precision severing of the hardest quartz glass in chip materials.
Long Zhang, Jin Xie, Aodian Guo
openaire   +3 more sources