Results 91 to 100 of about 7,277,805 (309)

Using DOProC method in reliability assessment of steel elements exposed to fatigue

MATEC Web of Conferences, 2017
Fatigue crack damage depends on a number of stress range cycles. This is a time factor in the course of reliability for the entire designed service life.
Krejsa Martin, Brozovsky Jiri, Mikolasek David, Lehner Petr, Parenica Premysl   +4 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Research on hydrogen-induced cracking behavior of normalized pipeline steel

MATEC Web of Conferences, 2018
Hydrogen sulfide corrosion test was used to test the hydrogen-induced cracking sensitivity of the normalized BNS pipeline steel. The microstructure and morphology of hydrogen induced crack(HIC) of the normalized BNS pipeline steel after hydrogen sulfide ...
Zhang Hai, Li Shaopo, Ding Wenhua, Hao Ning   +3 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Peridynamics analysis of crack propagation in concrete considering random aggregate distribution

Scientific Reports
The mechanical properties and fracture behavior of concrete are controlled by aggregate characteristics, and the distribution of aggregates is uncertain. Traditional studies on concrete crack propagation mainly conduct deterministic analysis based on the
Bin Geng, Ze Li, Yigong Zhao, Xiaoyan Zhang   +3 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Influence of different sizes of concrete and roller compacted concrete on double-K fracture parameters

Fracture and Structural Integrity, 2015
Affected by physical properties of various components, characteristics and stress states of junction surface and other multiple factors, concrete, as a kind of multi-phase composite material, has complicated failure mechanism, thus making its fracture ...
Liu Chunjiang, Zhang Huabo, Lv Ninghua
doaj  

Study on the crack self-healing performance of nano-micro silica modified hydrogel

矿业科学学报
The self-healing technology of cement-based materials is an important field of research for the timely and effective repair of engineering materials.
MA Mengyang, LI Ting, WANG Tie, LONG Yong, SU Ying, YANG Jin   +5 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Size effects in fatigue crack growth in confined volumes: A microbending case study on nanocrystalline nickel

Materials & Design
Mechanical size effects are a well known phenomenon when the sample volume is reduced or the characteristic length of the microstructure is changed. While size effects in micropillar compression (smaller is stronger) or due to grain refinement (Hall ...
Jutta Luksch, Aloshious Lambai, Gaurav Mohanty, Christoph Pauly, Florian Schaefer, Christian Motz   +5 more
doaj   +1 more source