Results 31 to 40 of about 7,277,805 (309)
Fracture Mechanical Behavior of Cracked Cantilever Roof with Large Cutting Height Mining
Shock and Vibration, 2020 Accurately predicting the roof collapse span is crucial in ensuring the safe production of thick seam mining with large mining height, which is easy in forming a “cantilever beam” structure.
Zenghui Zhao +4 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Influence of different sizes of concrete and roller compacted concrete on double-K fracture parameters [PDF]
Fracture and Structural Integrity, 2016 Affected by physical properties of various components, characteristics and stress states of junction surface and other multiple factors, concrete, as a kind of multi-phase composite material, has complicated failure mechanism, thus making its fracture ...
Liu Chunjiang, Zhang Huabo, Lv Ninghua
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Research on the Development Mechanism of Three Kinds of Cracks in Rock Cutting
Applied Sciences, 2023 In order to study the mechanism of crack propagation in rock cutting, experiments and discrete element numerical simulation of rock cutting at different depths were adopted in this paper. The rock fragmentation can be divided into mini-size fragmentation
Juntao Ma +4 more
doaj +1 more source
Italian National Conference on Sensors, 2021 This paper proposes a customized convolutional neural network for crack detection in concrete structures. The proposed method is compared to four existing deep learning methods based on training data size, data heterogeneity, network complexity, and the ...
Luqman Ali +5 more
semanticscholar +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source