Results 51 to 60 of about 7,277,805 (309)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PLASTICITY AREA AT THE THREE DIMENSIONAL CURVED ELASTICITY-PLASTICITY CRACK TIP UNDER QUASI-STATIC LOAD

Jixie qiangdu, 2018
In this article,three dimensional elastic-plastic curved crack tip plasticity area under quasi-static loads has been mainly studied,and three dimensional curved crack tip plasticity area has been calculated as a practical application of a second order ...
YANG DaPeng, PAN HaiYang, ZHANG PinPing, YANG XinHua   +3 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Mechanism of crack branching in the fatigue crack growth path of 2324-T39 Aluminium alloy

Fracture and Structural Integrity, 2015
The crack growth behavior in 2324-T39 aluminium alloy was experimentally investigated. Two types of crack branching were observed. The mechanism of an uncommon crack branching which results from the link up of secondary crack with the main crack was ...
Lu Songsong, Bao Rui, Zhang Ting, Fei Binjun   +3 more
doaj  

Fracture behaviors of pre-cracked monolayer molybdenum disulfide: A molecular dynamics study

Beilstein Journal of Nanotechnology, 2016
The fracture strength and crack propagation of monolayer molybdenum disulfide (MoS2) sheets with various pre-existing cracks are investigated using molecular dynamics simulation (MDS).
Qi-lin Xiong, Zhen-huan Li, Xiao-geng Tian   +2 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

In-situ SEM analysis of plastic deformation, crack initiation, crack propagation behaviors in M2 high speed steel

Journal of Materials Research and Technology
The plastic deformation, crack initiation, crack propagation behaviors of M2 high speed steel were investigated by means of in-situ SEM observation during tensile.
Lihui Zhu, Weiwei Zhang, Ruiyun Shi, Guoliang Wang   +3 more
doaj   +1 more source

The effect of white etching layer patches on a larger rail defect

MATEC Web of Conferences, 2017
Manufacturing defects such as porosity that formed in the rail could result in catastrophic failure if it remain in service. In this study, a crack that initiated from a large void was modelled using boundary element model to investigate the effect of ...
Sanusi Shahmir Hayyan, Fletcher David
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Observation of the initial process of internal fracture in very high cycle fatigue in Ti-6Al-4V by synchrotron radiation μCT imaging

Nihon Kikai Gakkai ronbunshu, 2017
The initiation and growth of internal small fatigue cracks with around ten or several dozen μm in Ti-6Al-4V were nondestructively examined by using synchrotron radiation μCT at the large synchrotron radiation facility SPring-8.
Fumiyoshi YOSHINAKA, Takashi NAKAMURA, Kazuaki TAKAKU, Daiki SHIOZAWA, Yoshikazu NAKAI, Kentaro UESUGI   +5 more
doaj   +1 more source