Results 61 to 70 of about 7,277,805 (309)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPACT OF HARDENING ON PLASTICITY AREA AT THE SLIGHTLY CURVED ELASTICITY-PLASTICITY CRACK TIP UNDER QUASI-STATIC LOADS

open access: yesJixie qiangdu, 2015
In this article,elastic-plastic curved crack tip plasticity area in hardened material under quasi-static loads has been mainly studied,and curved crack tip plasticity area has been calculated as a practical application of a second order perturbation ...
YANG DaPeng, WANG JianXun, ZHAO Yao
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Analytical solution on dosage of self-healing capsules in materials with two-dimensional multi-shaped crack patterns

open access: yesScience and Engineering of Composite Materials, 2018
This article presents a numerical method for determining the dosage of pre-embedded capsules in self-healing materials with complex crack patterns. The crack distribution on the surface of materials is simplified into a two-dimensional (2D) multi-shaped ...
Lin Jianjun   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

An Improved Method for Hull Structure Fatigue Crack Growth at Random Loading and Its Application

open access: yesJournal of Marine Science and Engineering
Under random wave loading, the crack growth rate exhibits jump-like cycle-to-cycle variations, which limit the direct use of efficient integration schemes such as the Euler method.
Ming Zhang   +3 more
doaj   +1 more source

Influence of Particulate Reinforcement and Equal-Channel Angular Pressing on Fatigue Crack Growth of an Aluminum Alloy

open access: yesMetals, 2015
The fatigue crack growth behavior of unreinforced and particulate reinforced Al 2017 alloy, manufactured by powder metallurgy and additional equal-channel angular pressing (ECAP), is investigated.
Lisa Köhler   +2 more
doaj   +1 more source

Vibration Response Analysis of Last Stage LP Turbine Blades for Variable Size of Crack in Root

open access: yes, 2016
This paper is intended to find the variation in vibration response of blades with the crack size of fir tree root free standing blades. Generation of crack in blade root causes the loss of stiffness in the vicinity of blade root.
A. Shukla, S. P. Harsha
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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