Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Prediction of fretting crack propagation based on a short crack methodology [PDF]
, 2008 Fretting tests have been conducted to determine the maximum crack extension under partial slip conditions, as a function of the applied tangential force amplitude.
Hills, David +10 more
core +1 more source
Experimental Study on Crack Width of HRB600 Grade High-Strength Steel Bar Reinforced Concrete Beams
Buildings, 2023 High-strength reinforcement is an important direction in the development of civil engineering. In order to fill the gap that the current concrete structure code GB50010 has no standard regulations applicable to HRB600-grade high-strength reinforcement ...
Xiaoyi Hu +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Calculation of crack width and crack spacing [PDF]
, 2007 The present paper discusses crack propagation and special attention is given to how the combined effect of reinforcement and fibre bridging influences the crack spacing and width in the serviceability limit state.
L\uf6vgren, Ingemar, Löfgren, Ingemar
core
Double cracks with single-inclusion fatigue propagation of surface-quenched large modulus rack
Advances in Mechanical Engineering, 2019 A connectivity criterion based on the analysis of the stress intensity factor for the double cracks and inclusion was developed to study the residual life of large modulus crack.
Xionghao Cheng +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Numerical analyses of crack spacing due to shrinkage in reinforced concrete slabs [PDF]
, 2003 Shrinkage cracking is commonly observed in concrete flat structures such as highway pavements,\ud slabs, and bridge decks. Crack spacing due to shrinkage has received considerable attention for many\ud years [1-3].
Baker, G., Chen, G.
core
Introduction of a fretting-fatigue mapping concept: Development of a dual crack nucleation - crack propagation approach to formalize fretting-fatigue damage [PDF]
, 2009 Fretting-fatigue induced by combined localized cyclic contact motion and external bulk fatigue loadings may result in premature and dramatic failure of the contacting components.
Kubiak, K.J. +3 more
core +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source