Results 51 to 60 of about 403,344 (296)

Predicting crack spacing of reinforced concrete tension members using strain compliance approach with debonding

Journal of Civil Engineering and Management, 2019
A novel technique based on strain compliance for investigating the crack spacing of reinforced concrete (RC) tension members has been developed. The new method is based on the mean strain and the partial interaction (stress-transfer) approaches.
Gintaris Kaklauskas, Regimantas Ramanauskas, Pui-Lam Ng   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Study on Crack Growth Resulting from Spacing and Alignment of Two Circular Holes: A Phase Field Approach

Computer Assisted Methods in Engineering and Science
This study investigates the effects of spacing and alignment between two circular holes on crack growth simulation. Key aspects analyzed include: (a) crack growth behavior, (b) von Mises stress distribution, and (c) energy profiles, all through ...
Sayahdin Alfat
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluation of the intrinsic crack growth rates of weld joints [PDF]

, 2011
A method is presented for evaluating weld intrinsic fatigue crack growth rate (FCGR) by excluding the influence of residual stresses. The method is potentially useful for predicting crack growth lives of structural components using measured FCGR data ...
Xiang Zhang, Rui Bao, Bao, Rui, Zhang, Xiang   +3 more
core   +1 more source

Numerical Analysis of Fracture Behaviour on Marble Samples Containing Two Flaws

Advances in Civil Engineering, 2020
Uniaxial compression tests were conducted on marble specimens containing two flaws. There are coplanar flaws and noncoplanar flaws. The inclination angle and spacing of flaws were considered of the coplanar flaws model, and the step angle and spacing of ...
Lifei Zheng, Dan Huang, Xiaoqing Li, Xuan Hu   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Study on Crack Development of Frame Beams with U-Shaped Engineered Cementitious Composites Cover Layer Under Negative Moments

Applied Sciences
In order to enhance the durability of concrete frame beams, a U-shaped engineered cementitious composites (ECC) protective layer is applied at the end of the frame beams.
Yuqing Yang, Hongyue Yang, Zhelong Jiang, Zaigen Mu   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Size effects on residual stress and fatigue crack growth in friction stir welded 2195-T8 aluminium - Part I: Experiments [PDF]

, 2011
Residual stress fields were measured in three different sizes of Compact-Tension (C(T)) and eccentrically loaded single edge notch (ESE(T)) specimens containing transverse or longitudinal welds. The effect of size on residual stress profiles was studied.
Irving, Phil E., P. Staron, T. Fischer, Ma, Yu E., Staron, P., Fischer, T., P.E. Irving, Yu E. Ma   +7 more
core   +1 more source