Results 211 to 220 of about 6,057 (299)

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Heterogeneity-Driven Strengthening and Hardening in Heterostructured Materials: Modeling and Simulation Across Length Scales. [PDF]

Materials (Basel)
Zhou C, Rohoman MM, Li N.
europepmc   +1 more source

From Ambition to Action: Barriers and Enablers for the Inclusion of Indigenous Peoples and Local Communities in the Kunming–Montreal Biodiversity Framework and the Role of Non‐State Bridge Organizations

Advanced Science, EarlyView.
Graphical abstract illustrating the transition from global biodiversity ambition to on‐the‐ground implementation of the Kunming–Montreal Global Biodiversity Framework after COP16, highlighting the roles of governments, non‐state actors, scientific knowledge systems, and resource mobilization in achieving transformative biodiversity outcomes.
Susan Enechojo Ogbe, Jinfeng Zhou, Linda Wong, Jiachen Gao   +3 more
wiley   +1 more source

Comparative Analysis of XFEM and Phase Field Approaches for Fracture Prediction in Flexible Ti-6Al-4V Thoracic Implants. [PDF]

J Funct Biomater
Bolaños A, Yánez A, Cuadrado A, Fiorucci MP.   +3 more
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

A Theoretical Solution for Analyzing Bi-Layer Structures with Differing Thermal Properties. [PDF]

Micromachines (Basel)
Peng Q, Zhou S, Shi Y, Qian X.
europepmc   +1 more source

Spike‐Embedded Nanocatalysts via Metal‐Directed Carbonization for Highly Efficient and Robust Semi‐Hydrogenation

Advanced Science, EarlyView.
A metal‐directed carbonization strategy transforms hierarchical organic microspheres into spiky carbon catalysts with Pd nanoparticles embedded at the tips. This approach resolves the activity‐stability trade‐off, achieving exceptional poison resistance in semi‐hydrogenations, offering a versatile, scalable platform for designing high‐performance ...
Yintao Li, Yang Sun, Minghang Li, Wenxuan Zhang, Zhengtao Li, Yihao Ni, Yao Zhang, Yong Wang, Samuel S. Veroneau, Pengfei Ji   +9 more
wiley   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Systematic Evaluation of Strain Rate and Environmental Conditions Effects on Stress Corrosion Cracking of an Al-Cu Alloy. [PDF]

Materials (Basel)
Lorenzi S, Nani L, Ferrari S, Locatelli M, Gritti L, Bocchi S, Cabrini M.   +6 more
europepmc   +1 more source

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source