Results 91 to 100 of about 636,508 (285)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Energy radiation of moving cracks

, 2001
The energy radiated by moving cracks in a discrete background is analyzed. The energy flow through a given surface is expressed in terms of a generalized Poynting vector. The velocity of the crack is determined by the radiation by the crack tip.
A. Karma, A. Yuse, D.A. Kessler, D.A. Kessler, D.A. Kessler, D.A. Kessler, E. Louis, E. Louis, E. Sharon, E. Sharon, E. Sharon, E.H. Yoffe, F. Guinea, F.F. Abraham, H. Larralde, I.S. Aranson, J. Fineberg, J. Fineberg, J.A. Hauch, J.F. Boudet, J.F. Boudet, J.F. Boudet, J.F. Boudet, J.M. Morrissey, J.M. Morrissey, J.R. Willis, K.N.G. Fuller, L.B. Freund, L.B. Freund, L.I. Slepyan, L.I. Slepyan, L.M. Sander, M. Adda-Bedia, M. Adda-Bedia, M. Marder, O. Pla, O. Pla, O. Pla, O. Pla, P. González, P. Meakin, R.K. Kalia, S. Fratini, S. Ramanathan, S.J. Zhou, Sh.A. Kulamekhtova, T. Martín   +46 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Investigation of Lateral Stress Relief on theStability of PHI = 0 DEG Slopes Using Laboratory, Fracture Mechanics, and Finite Element Method Approaches [PDF]

, 2011
Total stress analyses of purely cohesive cut slopes utilize the undrained shear strength for slope stability analyses. These slopes can have an in-situ lateral earth pressure that is greater than the vertical pressure.
Kutschke, Walter
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Size scaling of strength in thin film delamination

, 2011
We investigate by numerical simulation the system size dependence of the shear delamination strength of thin elastic films. The films are connected to a rigid substrate by a disordered interface containing a pre-existing crack. The size dependence of the
Alava M J, Bazant Z P, M Zaiser, Zaiser M, Zaiser M   +4 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Microscopic evaluation of a polyimide (PMR-15)-graphite composite [PDF]

, 1985
An effort to evaluate the high temperature performance of a polyimide (PMR-15)-graphite composite which consists of several plies of woven strands of carbon fibers was undertaken. The longterm effect of high temperature on the dry material was studied by
Augl, J. M., Fedderly, J. J.
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Experimental Study on the Strength and Damage Characteristics of Cement–Fly Ash–Slag–Gangue Cemented Backfill

Buildings
In order to achieve the goal of effectively utilizing solid waste resources and improving mining stability, it is necessary to incorporate various types of solid wastes in the production of cemented backfill.
Baofeng Song, Heyu Li, Ran An, Xianwei Zhang, Zefeng Zhou   +4 more
doaj   +1 more source