Results 91 to 100 of about 555,809 (235)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Crack Segmentation Model Based on Deformable Convolution and Cross‐Stage Feature Fusion Network

IET Intelligent Transport Systems
To address the issues of false positives and missed detections of multi‐scale cracks and small targets in complex environments, this paper proposes an enhanced YOLOv10 instance segmentation network named YOLO‐RCS (YOLOv10s road crack segmentation ...
Mohammed Al‐Soswa, Zhaoyun Sun, Ali Desbi, Abdulkareem Abdullah   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hot ductility and fracture mechanism of Fe-22Mn-0.7C TWIP steel

工程科学学报, 2016
The static tensile behaviors of Fe-22Mn-0.7C TWIP steel and Q235 steel between 700 ℃ and 1300 ℃ were investigated by Gleeble-1500 thermo-mechanical simulator.The microstructure characteristic and fracture morphology were observed by optical microscopy ...
LAN Peng, TANG Hai-yan, JI Yuan, DU Chen-wei, ZHANG Jia-quan   +4 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Corrosion resistance of zinc-based systems in NaCl environment

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013
Metal components in engineering, industry and agriculture are subjects of degradation process influenced by corrosion which result in changes of mechanical characteristics.
Jiří Votava
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Finding and Filling the "Cracks" In Resistance Surfaces for Least-cost Modeling

Ecology and Society, 2005
Least-cost modeling is an increasingly popular method used to measure the effective distance between habitat patches and to assess the connectivity of existing landscapes or potential reserves.
Kristina Rothley
doaj   +1 more source

A study of the porosity of nuclear graphite using small-angle neutron scattering [PDF]

, 2013
Small angle neutron scattering (SANS) measures porosity in nuclear graphites, including both open pores, caused by escaping decomposition gases, and internal cracks (in coke particles) generated by anisotropic thermal contraction along the c-direction ...
Bale, D.K. Ross, Hacker, Heenan, Heggie, Hoinkis, Hoinkis, Ibel, Latham, Mandelbrot, Martin, Martin, Martin, Martin, S.M. King, Wen, Winter, Z. Mileeva   +17 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source