Results 131 to 140 of about 555,809 (235)

Effect of Drying and Wetting Cycles on the Surface Cracking and Hydro-Mechanical Behavior of Expansive Clays

Buildings
Expansive clays present serious issues in a variety of engineering applications, including roadways, light buildings, and infrastructure, because of their notable volume changes with varying moisture content.
Abdullah A. Shaker, Muawia Dafalla, Ahmed M. Al-Mahbashi, Mosleh A. Al-Shamrani   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Numerical prediction of crack formation in historic masonry buildings

Magazine of Civil Engineering
This article investigated mechanical behavior of the masonry of historic buildings. It was assumed that reliable cracking processes can be obtained by modeling masonry as a continuous medium and using the Jointed Masonry Model (JMM).
Iovlev Gregorii, Belov Nikita, Zileev Aleksandr   +2 more
doaj   +1 more source

ON CRACK CLOSURE IN FATIGUE CRACK GROWTH

, 1978
A brief review of the various forms of closure is given, and the relative importance of plasticity-induced closure and roughness-induced closure is considered. On the basis of the lack of a thickness effect and an insensitivity to R in the absence of closure it is concluded that plasticity-induced closure plays a relatively minor role in affecting the ...
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Fissure evolution and variation of pyrolysis kinetics parameters of tar-rich coal during heat treatment under different atmosphere

Meitan kexue jishu
The clean and efficient development of tar-rich coal is helpful in ensuring China's energy security. The tar-rich coal from Ningtiaota Mine was selected and heated under N2 and hypoxia atmosphere.
Shuangming WANG, Qiang SUN, Xin HU, Zhenlong GE, Jishi GENG, Shengze XUE, Qingmin SHI   +6 more
doaj   +1 more source

Crack growth criteria and crack tip models

, 1988
Summary: The current status of crack tip characterizations is reviewed. Several unresolved areas for further research are identified. Singular fields for stationary and moving crack tips in different nonlinear materials are reviewed and special emphasis is put on the extension of the region where these fields dominate.
Nilsson, Fred, Ståhle, P.
openaire   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Transverse cracks in a strip with reinforced surfaces [PDF]

The symmetrical problem of two transverse cracks in an elastic strip with reinforced surfaces is formulated in terms of a singular integral equation. The special cases of one central crack or two edge cracks are discussed.
Bakioglu, M., Krenk, S.
core   +1 more source