Results 81 to 90 of about 636,508 (285)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Hot ductility and fracture mechanism of Fe-22Mn-0.7C TWIP steel
工程科学学报, 2016 The static tensile behaviors of Fe-22Mn-0.7C TWIP steel and Q235 steel between 700 ℃ and 1300 ℃ were investigated by Gleeble-1500 thermo-mechanical simulator.The microstructure characteristic and fracture morphology were observed by optical microscopy ...
LAN Peng +4 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Corrosion resistance of zinc-based systems in NaCl environment
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013 Metal components in engineering, industry and agriculture are subjects of degradation process influenced by corrosion which result in changes of mechanical characteristics.
Jiří Votava
doaj +1 more source
Reduced models for linearly elastic thin films allowing for fracture, debonding or delamination [PDF]
, 2015 This work is devoted so show the appearance of different cracking modes in linearly elastic thin film systems by means of an asymptotic analysis as the thickness tends to zero.
Babadjian, Jean-Francois, Henao, Duvan
core +4 more sources
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Finding and Filling the "Cracks" In Resistance Surfaces for Least-cost Modeling
Ecology and Society, 2005 Least-cost modeling is an increasingly popular method used to measure the effective distance between habitat patches and to assess the connectivity of existing landscapes or potential reserves.
Kristina Rothley
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
TIG Dressing Effects on Weld Pores and Pore Cracking of Titanium Weldments
Metals, 2016 Weld pores redistribution, the effectiveness of using tungsten inert gas (TIG) dressing to remove weld pores, and changes in the mechanical properties due to the TIG dressing of Ti-3Al-2.5V weldments were studied.
Hui-Jun Yi, Yong-Jun Lee, Kwang-O Lee
doaj +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source