Results 1 to 10 of about 68,059 (240)

Exploring the Intricate Links between Adenotonsillar Hypertrophy, Mouth Breathing, and Craniofacial Development in Children with Sleep-Disordered Breathing: Unraveling the Vicious Cycle. [PDF]

Children (Basel), 2023
Adenotonsillar hypertrophy has been well-acknowledged as the primary instigator of sleep-disordered breathing in the pediatric population. This condition spans a spectrum, from typical age-related growth that the immune system influences to persistent ...
Nosetti L, Zaffanello M, De Bernardi di Valserra F, Simoncini D, Beretta G, Guacci P, Piacentini G, Agosti M.   +7 more
europepmc   +2 more sources

Sonic hedgehog signaling in craniofacial development. [PDF]

Differentiation, 2023
Mutations in SHH and several other genes encoding components of the Hedgehog signaling pathway have been associated with holoprosencephaly syndromes, with craniofacial anomalies ranging in severity from cyclopia to facial cleft to midfacial and mandibular hypoplasia.
Xu J, Iyyanar PPR, Lan Y, Jiang R.
europepmc   +3 more sources

Fine-tuning of Wnt signaling by RNA surveillance factor Smg5 in the mouse craniofacial development. [PDF]

iScience
Summary: The specific roles of nonsense-mediated mRNA decay (NMD), a translation-dependent RNA quality control mechanism that degrades mRNAs containing premature termination codons (PTCs), in mammalian craniofacial development have remained unclear. Here,
Zhu S, Huo S, He W, Huang C, Zhang J, Jiang X, Qian Y, Chen C, Dai ZM, Yang X, Qiu M, Li T, Zhu XJ.   +12 more
europepmc   +2 more sources

Dynamic enhancer landscapes in human craniofacial development. [PDF]

Nat Commun
The genetic basis of human facial variation and craniofacial birth defects remains poorly understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal expression of genes during critical stages of craniofacial development ...
Rajderkar SS, Paraiso K, Amaral ML, Kosicki M, Cook LE, Darbellay F, Spurrell CH, Osterwalder M, Zhu Y, Wu H, Afzal SY, Blow MJ, Kelman G, Barozzi I, Fukuda-Yuzawa Y, Akiyama JA, Afzal V, Tran S, Plajzer-Frick I, Novak CS, Kato M, Hunter RD, von Maydell K, Wang A, Lin L, Preissl S, Lisgo S, Ren B, Dickel DE, Pennacchio LA, Visel A.   +30 more
europepmc   +2 more sources

Transforming growth factor beta signaling and craniofacial development: modeling human diseases in zebrafish. [PDF]

Front Cell Dev Biol
Humans and other jawed vertebrates rely heavily on their craniofacial skeleton for eating, breathing, and communicating. As such, it is vital that the elements of the craniofacial skeleton develop properly during embryogenesis to ensure a high quality of
Fox SC, Waskiewicz AJ.
europepmc   +2 more sources

Integrative analysis of transcriptome dynamics during human craniofacial development identifies candidate disease genes. [PDF]

Nat Commun, 2023
Craniofacial disorders arise in early pregnancy and are one of the most common congenital defects. To fully understand how craniofacial disorders arise, it is essential to characterize gene expression during the patterning of the craniofacial region.
Yankee TN, Oh S, Winchester EW, Wilderman A, Robinson K, Gordon T, Rosenfeld JA, VanOudenhove J, Scott DA, Leslie EJ, Cotney J.   +10 more
europepmc   +2 more sources

Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity

Scientific Reports, 2022
Tooth roots embedded in the alveolar bone do not typically undergo resorption while the bone continues remodeling in its physiological state.
Hwajung Choi, Liu Yang, Yudong Liu, Ju-Kyung Jeong, Eui-Sic Cho   +4 more
doaj   +1 more source

Salivary peptidome analysis and protease prediction during orthodontic treatment with fixed appliances

Scientific Reports, 2023
Orthodontic tooth movement (OTM) occurs through proteolytic remodelling within the periodontium following the application of external force to the tooth.
Fidaa Wazwaz, Hayder Saloom, Jack W. Houghton, Martyn T. Cobourne, Guy H. Carpenter   +4 more
doaj   +1 more source

Supplemental Ferulic Acid Inhibits Total Body Irradiation-Mediated Bone Marrow Damage, Bone Mass Loss, Stem Cell Senescence, and Hematopoietic Defect in Mice by Enhancing Antioxidant Defense Systems

Antioxidants, 2021
While total body irradiation (TBI) is an everlasting curative therapy, the irradiation can cause long-term bone marrow (BM) injuries, along with senescence of hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) via reactive oxygen species ...
Sajeev Wagle, Hyun-Jaung Sim, Govinda Bhattarai, Ki-Choon Choi, Sung-Ho Kook, Jeong-Chae Lee, Young-Mi Jeon   +6 more
doaj   +1 more source

RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1

eLife, 2020
Mutations in the gene encoding Ras-associated binding protein 23 (RAB23) cause Carpenter Syndrome, which is characterized by multiple developmental abnormalities including polysyndactyly and defects in skull morphogenesis.
Md Rakibul Hasan, Maarit Takatalo, Hongqiang Ma, Ritva Rice, Tuija Mustonen, David PC Rice   +5 more
doaj   +1 more source