Preclinical Models of Craniospinal Irradiation for Medulloblastoma [PDF]
Cancers, 2020 Medulloblastoma is an embryonal tumor that shows a predilection for distant metastatic spread and leptomeningeal seeding. For most patients, optimal management of medulloblastoma includes maximum safe resection followed by adjuvant craniospinal irradiation (CSI) and chemotherapy. Although CSI is crucial in treating medulloblastoma, the realization that
Jennifer L. Stripay +3 more
openaire +3 more sources
Craniospinal irradiation of medulloblastoma in the supine position [PDF]
Reports of Practical Oncology & Radiotherapy, 2006 SummaryBackgroundMedulloblastoma, a primitive neuroectodermal tumour growing in the cerebellum, is one of the most sensitive childhood brain tumours to radiation therapy. The most common malignant CNS tumour of children is medulloblastoma with an overall incidence among children aged 0–19 years of 16–20% of all paediatric brain tumours. Radiotherapy is
Slampa, Pavel +8 more
core +4 more sources
A feasibility study using TomoDirect for craniospinal irradiation [PDF]
Journal of Applied Clinical Medical Physics, 2013 The feasibility of delivering craniospinal irradiation (CSI) with TomoDirect is investigated. A method is proposed to generate TomoDirect plans using standard three‐dimensional (3D) beam arrangements on Tomotherapy with junctioning of these fields to minimize hot or cold spots at the cranial/spinal junction.
Langner, Ulrich W. +3 more
openaire +3 more sources
A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease [PDF]
Frontiers in Oncology, 2023 BackgroundDiffuse midline glioma (DMG) is an aggressive pediatric central nervous system tumor with strong metastatic potential. As localized treatment of the primary tumor improves, metastatic disease is becoming a more important factor in treatment. We
Aaron J. Knox +17 more
doaj +2 more sources
Clinical Implementation of Robust Optimization for Craniospinal Irradiation [PDF]
Cancers, 2018 With robust optimization for spot scanning proton therapy now commercially available, the ability exists to account for setup, range, and interfield uncertainties during optimization. Robust optimization is particularly beneficial for craniospinal irradiation (CSI) where the large target volume lends itself to larger setup uncertainties and the need ...
Alexandria Tasson +2 more
openaire +3 more sources
Static-junction craniospinal irradiation: verification of daily dose and long-term treatment results [PDF]
Nowotwory, 2021 INTRODUCTION: The study was performed to evaluate the repeatability and effectiveness of the static-junctions image guided (SJIG) method of craniospinal irradiation. MATERIAL AND METHODS: An analysis of 40 treatment plans was performed.
Aleksandra Napieralska +3 more
doaj +4 more sources
Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation [PDF]
Radiation Oncology, 2006 Background Medulloblastoma and other types of tumors that gain access to the cerebrospinal fluid can spread throughout the craniospinal axis. The purpose of this study was to devise a simple multi-compartment kinetic model using established tumor cell ...
Halperin Edward C +3 more
doaj +3 more sources
Hypothyroidism due to Cranial and Craniospinal Irradiation
Клиническая и экспериментальная тиреоидология, 2013 Благодаря успехам современной онкологии общая пятилетняя выживаемость при онкологических заболеваниях у детей и подростков составляет в целом 75% [4]. Большой вклад в эти достижения привнесло применение лучевой терапии (ЛТ) в составе комплексного лечения
E I Bobrova +4 more
doaj +3 more sources
Pulmonary toxicity of craniospinal irradiation using helical tomotherapy [PDF]
Scientific Reports, 2022 Craniospinal irradiation using helical tomotherapy (HT-CSI) has advantages in aspects of homogeneous dose distribution. Physicians, however, still have concerns of pulmonary toxicity due to HT-CSI’s relatively large, low-dose irradiated volume from ...
Joongyo Lee +5 more
doaj +4 more sources
Preservation of Ovarian Germinal Follicles by Temporary Laparoscopic Ovarian Transposition in Teenaged Girls Undergoing Craniospinal Irradiation for Radiosensitive Central Nervous System Tumors [PDF]
Taiwanese Journal of Obstetrics & Gynecology, 2008 Objective: To report the efficacy of laparoscopic ovarian transposition procedure in teenaged girls for preventing ovarian damage from craniospinal radiation therapy.
Fu-Tsai Kung +4 more
doaj +2 more sources