Results 51 to 60 of about 370,481 (201)

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Bortezomib‐based chemotherapy in Chinese pediatric patients with relapsed/refractory acute lymphoblastic leukemia: A single‐center retrospective study

Pediatric Investigation, EarlyView.
Bortezomib‐based chemotherapy achieved an 88.9% remission rate in Chinese pediatric patients with relapsed/refractory B‐cell acute lymphoblastic leukemia, enabling 62.5% of responders to bridge to transplantation, while T‐cell acute lymphoblastic leukemia showed no response.
Xingyu Zhao, Jian Wang, Liping Que, Dunhua Zhou, Jianpei Fang, Luhong Xu   +5 more
wiley   +1 more source

Clinical trial of proton craniospinal irradiation for leptomeningeal metastases [PDF]

Neuro-Oncology, 2020
Abstract Background Leptomeningeal metastases (LM) are associated with limited survival and treatment options. While involved-field radiotherapy is effective for local palliation, it lacks durability.
T Jonathan Yang, Neil A Wijetunga, Josh Yamada, Suzanne Wolden, Michelle Mehallow, Debra A Goldman, Zhigang Zhang, Robert J Young, Mark G Kris, Helena A Yu, Andrew D Seidman, Igor T Gavrilovic, Andrew Lin, Bianca Santomasso, Christian Grommes, Anna F Piotrowski, Lauren Schaff, Jacqueline B Stone, Lisa M DeAngelis, Adrienne Boire, Elena Pentsova   +20 more
openaire   +2 more sources

Assessment of the results and hematological side effects of 3D conformal and IMRT/ARC therapies delivered during craniospinal irradiation of childhood tumors with a follow-up period of five years

BMC Cancer, 2020
Background Craniospinal irradiation (CSI) of childhood tumors with the RapidArc technique is a new method of treatment. Our objective was to compare the acute hematological toxicity pattern during 3D conformal radiotherapy with the application of the ...
Zoltán Lőcsei, Róbert Farkas, Kornélia Borbásné Farkas, Klára Sebestyén, Zsolt Sebestyén, Zoltán Musch, Ágnes Vojcek, Noémi Benedek, László Mangel, Gábor Ottóffy   +9 more
doaj   +1 more source

Echocardiographic myocardial strain analysis describes subclinical cardiac dysfunction after craniospinal irradiation in pediatric and young adult patients with central nervous system tumors

Cardio-Oncology, 2021
Background Craniospinal irradiation (CSI) is part of the treatment of central nervous system (CNS) tumors and is associated with cardiovascular disease in adults.
Hugo R. Martinez, Ralph Salloum, Erin Wright, Lauren Bueche, Philip R. Khoury, Justin T. Tretter, Thomas D. Ryan   +6 more
doaj   +1 more source

Craniospinal irradiation by volumetric modulated arc therapy technique on halcyon

Journal of Radiation and Cancer Research, 2022
Aims: Craniospinal irradiation (CSI) is a challenging task on halcyon due to its field size constraint (28 cm × 28 cm). CSI was planned by volumetric modulated arc therapy (VMAT) technique on Halcyon (6MV) linac with no junction shift with multiple arcs ...
Shubhangi Barsing, Anand Parab, Anuradha Singh, Gopal Pemmaraju   +3 more
doaj   +1 more source

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

Brain Pathology, EarlyView.
Resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Chitra Sarkar, Maysa Al‐Hussaini, Vani Santosh, Vaishali Suri, Sung‐Hye Park, Yue‐Shan Piao, Tarik Tihan, Ho‐Keung Ng, Michael Buckland, Rakesh Jalali, Yonehiro Kanemura, Pieter Wesseling, Takashi Komori   +12 more
wiley   +1 more source

Craniospinal irradiation as part of re-irradiation for children with recurrent intracranial ependymoma [PDF]

Neuro-Oncology, 2018
The goal of this study was to evaluate outcomes in children with relapsed, molecularly characterized intracranial ependymoma treated with or without craniospinal irradiation (CSI) as part of a course of repeat radiation therapy (re-RT).This was a retrospective cohort study of 31 children. Patients with distant relapse received CSI as part of re-RT. For
Tsang, DS, Murray, L, Ramaswamy, V, Zapotocky, M, Tabori, U, Bartels, U, Huang, A, Dirks, PB, Taylor, MD, Hawkins, C, Bouffet, E, Laperriere, N   +11 more
openaire   +3 more sources

Craniospinal Irradiation: A Dosimetric Comparison Between O-Ring Linac and Conventional C-arm Linac

Advances in Radiation Oncology, 2023
Purpose: The aim of this study was to perform a dosimetric evaluation between craniospinal irradiation volumetric modulated arc therapy plans designed for an O-Ring and a conventional C-arm Linac.
Theodoros Stroubinis, MSc, Michalis Psarras, MSc, Anna Zygogianni, PhD, Maria Protopapa, MD, Vassilis Kouloulias, PhD, Kalliopi Platoni, PhD   +5 more
doaj   +1 more source

Molecular profiling of pediatric medulloblastoma in Kazakhstan: Genomic alterations, subgroup distribution, and survival

Brain Pathology, EarlyView.
A practical formalin‐fixed, paraffin‐embedded (FFPE)‐based molecular workflow integrating pathology, immunohistochemistry, and genomic profiling provides clinically meaningful subgroup classification of pediatric medulloblastoma and expands molecular evidence from an underrepresented Central Asian population. Abstract Medulloblastoma is the most common
Aidos Bolatov, Askhat Zhakupov, Aizhan Abdikadirova, Malika Sapargaliyeva, Bakytkali Ibraimov, Zhanat Zhalimbetova, Gabit Ólenbay, Berik Zhetpisbayev, Xingzhi Xu, Mirgul Bayanova   +9 more
wiley   +1 more source