Results 41 to 50 of about 15,355 (176)

Presence of Emissary Veins in the Glabellar Region in Metopic Craniosynostosis

Clinical Anatomy, EarlyView.
ABSTRACT Emissary veins connect intra‐ and extracranial venous circulation by bridging the dural venous sinuses to the external veins of the skull. Their variable presence and location may have important implications in perioperative blood loss. Clinical observations and previous studies suggest that emissary veins are more frequently present in the ...
Anna Sundelin, Erik Ceder, Madiha Bhatti‐Søfteland, Giovanni Maltese, Peter Tarnow, Lars Kölby, Karin Säljö   +6 more
wiley   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

Percentage of mice with craniosynostosis by genotype.

, 2019
Mice that harbored mutations in both Twist1 (+/-) and Gsk3β(+/-) showed a significant increase in rate of craniosynostosis as compared to the expected additive outcome of Twist1 (+/-) and Gsk3β(+/-) independently (based on their individual rates of ...
Jonas A. Gustafson (7305425), Sarah S. Park (7305428), Michael L. Cunningham (7305431)   +2 more
core   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

FGF and TGFbeta signalling in an in-vitro model of craniosynostosis [PDF]

, 2009
Fibroblast Growth Factor (FGF) and Transforming Growth Factor beta (TGFbeta) are key regulators of bone development. Constitutively activating mutations of FGF Receptors (FGFR) 1-3 result in craniosynostosis, premature fusion of cranial sutures.
Lee, K.M.A.
core  

Craniosynostosis in Kabuki syndrome

, 2010
Niikawa-Kuroki, or Kabuki syndrome (KS), is characterized by distinctive facial features, skeletal anomalies, persisting fingertip pads with dermatoglyphic abnormalities, short stature, and mental retardation.
Juan F. Martínez-Lage, Antonio López López-Guerrero, Matías Felipe-Murcia, María-José Almagro, Encarna Guillén Navarro, Miguel A. Pérez-Espejo   +5 more
core   +1 more source

P38α MAPK-induced senescence in cranial suture progenitor cells promotes craniosynostosis

Communications Biology
Craniosynostosis is a congenital cranial developmental disorder that frequently leads to craniofacial deformities and even neurological dysfunction. The abnormalities in cranial suture progenitor cells (SPC) are considered a key event in craniosynostosis;
Zong Chen, Zhiyou Chen, Xinyan Chen, Yingying Yue, Yu Wang, Xueying Hou, Xiaoshuang Guo, Chenzhi Lai, Guodong Song, Xiaolei Jin   +9 more
doaj   +1 more source

Craniosynostosis of coronal suture in Twist1+/- mice occurs through endochondral ossification recapitulating the physiological closure of posterior frontal suture

Frontiers in Physiology, 2011
Craniosynostosis, the premature closure of cranial suture, is a pathologic condition that affects 1/2000 live births. Saethre-Chotzen syndrome is a genetic condition characterized by craniosynostosis.
Bjorn eBehr, Michael T Longaker, Natalina eQuarto, Natalina eQuarto   +3 more
doaj   +1 more source

Germline Cancer Predisposition and De Novo Contributions in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group

International Journal of Cancer, EarlyView.
ABSTRACT Approximately 6%–8% of children and adolescents with rhabdomyosarcoma (RMS) have an underlying cancer predisposition disorder (CPD), which varies between embryonal and alveolar subtypes and other clinical characteristics. Identifying a CPD remains challenging, as traditional approaches rely on clinical features and family history. Additionally,
Taylor M. Luckie, Sarah Scollon, Yao Yu, Aniko Sabo, Tiffany Chambers, Olga Taylor, Logan G. Spector, Michael E. Scheurer, Douglas S. Hawkins, Rajkumar Venkatramani, Chad D. Huff, Sharon E. Plon, Philip J. Lupo   +12 more
wiley   +1 more source