Results 61 to 70 of about 15,355 (176)
Identification of Novel Interacting Proteins of FUZ and GPR161
PROTEOMICS, EarlyView.ABSTRACT Protein–protein interactions are central to the dynamic regulation of signaling pathways and provide critical insight into the cellular mechanisms underlying human disease. Our previous study demonstrated biochemical and genetic interactions between FUZ and GPR161 in sonic hedgehog signaling during spinal neural tube development. In this study,
Gabriella Salazar +3 more
wiley +1 more source
Smart Molecules, EarlyView.A 3D‐bioprinted platform with stem cells activates “nerve‐bone” signaling by enabling the spatiotemporal delivery of Nell‐1. This activation enhances neurovascular and bone regeneration through the CYFIP1 cascade. In rat calvarial defects, the platform doubled bone regeneration and nerve repair and tripled vascular density, resulting in superior ...
Minjia Zhu +11 more
wiley +1 more source
An Overview of Modelling Craniosynostosis Using the Finite Element Method [PDF]
, 2019 Craniosynostosis is a medical condition caused by the early fusion of the cranial joint. The finite element method (FEM) is a computational technique that can answer a variety of “what if” questions in relation to the biomechanics of this condition.
Malde, O, Moazen, M, Libby, J
core +1 more source
Genetic testing in paediatric neurological disorders
Developmental Medicine &Child Neurology, EarlyView.In this study 390 paediatric patients with neurological disorders underwent genetic testing via exome sequencing, commercial panel, in‐house epilepsy, and movement disorder gene panels. Exome sequencing provides the highest diagnostic yield, and severe developmental delay and hypotonia predicted pathogenic variants in the exome sequencing cohort ...
Wafa Bani Uraba +15 more
wiley +1 more source
Pictorial essay: The many faces of craniosynostosis
, 2011 Craniosynostosis is a common condition in the pediatric age group, which may either be isolated or may present as part of a craniofacial syndrome. This pictorial review illustrates the underlying mechanisms and pathophysiology of craniosynostosis, the ...
Paritosh C Khanna +3 more
core +1 more source
Unisutural craniosynostosis: simple or complex? [PDF]
, 2017 The premature fusion of skull sutures, craniosynostosis, occurs in approximately 1 in 1500 births and results in a altered skull shape and increased risk of intracranial hypertension. This thesis focused on several aspects of unisutural craniosynostosis,
Cornelissen, M.J. (Martijn)
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Neuropsychological outcomes and health-related quality of life of children operated for nonsyndromic craniosynostosis [PDF]
, 2019 The primary aim of this thesis was to assess the intelligence quotient, attention function, adaptive behavior skills, and health-related quality of life of children operated for nonsyndromic craniosynostosis.
Kljajic, Marizela +10 more
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Craniosynostosis relationships with Cognitive, Behavioral and Emotional Functioning [PDF]
, 2019 The aim of the present thesis is to extend the existing knowledge on both the prevalence and etiology of (neuro)cognitive, behavioral and emotional problems in children with craniosynostosis.
Vlugt, J.J.B. (Joris) van der
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Journal of Pediatric Neurosciences, 2014 We are reporting a rare case of I-cell disease presenting with craniosynostosis. An 11-month-old child presented with abnormal head shape, developmental delay and bent bones. We planned for corrective surgery for craniosynostosis, but on genetic analysis
Lakshmanarao Chittem +2 more
doaj +1 more source
Oral Diseases, EarlyView.ABSTRACT Objective This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings. Materials and Methods A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for publications from January ...
Giorgia Pieretto +3 more
wiley +1 more source