Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. [PDF]
Neuron, 2020 The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines ...
Abumaria, Nashat +55 more
core +3 more sources
Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice [PDF]
Bone Research, 2017 Cre/loxP technology has been widely used to study cell type-specific functions of genes. Proper interpretation of such data critically depends on a clear understanding of the tissue specificity of Cre expression. The Dmp1-Cre mouse, expressing Cre from a
Burclaff, Joseph +4 more
core +3 more sources
Interfaces Numériques, 2022 L’école publique souhaite mettre dans les mains des élèves des ordinateurs, tablettes ou convertibles pour envisager l’éducation numérique. Les compétences d’usages numériques — au sens de maîtrise de l’utilisation — deviennent alors centrales pour ...
Mathieu Payn +2 more
doaj +1 more source
Developing an innovative artificial ecosystem in the wetlands of El Rym, Annaba (Algeria): The “3E garden” model for urban resilience [PDF]
E3S Web of ConferencesThe El Rym wetland (Annaba, Algeria) is a vital ecosystem for biodiversity, currently threatened by increasing anthropogenic pressure and the impacts of climate change.
Youbi Amira +6 more
doaj +1 more source
Characterization of Cre recombinase activity for in vivo targeting of adipocyte precursor cells. [PDF]
, 2014 The increased incidence of obesity and metabolic disease underscores the importance of elucidating the biology of adipose tissue development. The recent discovery of cell surface markers for prospective identification of adipose precursor cells (APCs) in
Costa, Maria José +3 more
core +2 more sources
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Nature Neuroscience, 2009 The Cre/lox system is widely used in mice to achieve cell-type-specific gene expression. However, a strong and universally responding system to express genes under Cre control is still lacking.
L. Madisen +11 more
semanticscholar +1 more source
Corporate real estate asset management : aligned vision [PDF]
, 2012 Purpose – The purpose of this paper is to evaluate the relationship between corporate strategy and corporate real estate (CRE) strategy. Design/methodology/approach – The paper will identify, and evaluate, a number of components that collectively form ...
Haynes, Barry
core +1 more source
The Potential Trajectory of Carbapenem-Resistant Enterobacteriaceae, an Emerging Threat to Health-Care Facilities, and the Impact of the Centers for Disease Control and Prevention Toolkit. [PDF]
, 2016 Carbapenem-resistant Enterobacteriaceae (CRE), a group of pathogens resistant to most antibiotics and associated with high mortality, are a rising emerging public health threat.
Bartsch, Sarah M +10 more
core +1 more source
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
BMC Developmental Biology, 2001 BackgroundSeveral Cre reporter strains of mice have been described, in which a lacZ gene is turned on in cells expressing Cre recombinase, as well as their daughter cells, following Cre-mediated excision of a loxP-flanked transcriptional "stop" sequence.
S. Srinivas +6 more
semanticscholar +1 more source
Optimization of tamoxifen-induced Cre activity and its effect on immune cell populations
Scientific Reports, 2020 Tamoxifen (TAM) inducible Cre recombinase system is an essential tool to study gene function when early ablation or overexpression can cause developmental defects or embryonic lethality. However, there remains a lack of consensus on the optimal route and
Rachel Donocoff +4 more
semanticscholar +1 more source