Results 111 to 120 of about 943,536 (329)
Short-Term and Highly Efficient Cas9 Expression System Using Adenovirus Vector and Site-Specific Recombinase Cre [PDF]
, 2021 Sayaka Nagamoto +5 more
openalex +1 more source
HSCB, a co-chaperone in mitochondrial iron-sulfur cluster biogenesis, is a novel candidate gene for congenital sideroblastic anemia [PDF]
, 2017 Congenital sideroblastic anemias (CSA) are inherited diseases resulting from defects in heme biosynthesis, mitochondrial iron-sulfur cluster (ISC) assembly, or mitochondrial translation.
Crispin, Andrew
core
Dark matter electron anisotropy: a universal upper limit
, 2010 We study the dipole anisotropy in the arrival directions of high energy CR electrons and positrons (CRE) of Dark Matter (DM) origin. We show that this quantity is very weakly model dependent and offers a viable criterion to discriminate among CRE from DM
Abbasi +50 more
core +1 more source
Advanced Science, EarlyView.Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen +16 more
wiley +1 more source
Characterization of Sirt2 using conditional RNAi in mice [PDF]
, 2011 Within the past eight years, RNA interference (RNAi) has emerged as a powerful experimental tool for gene function analysis in mice. Reversible control of shRNA mediated RNAi has been achieved by using a tetracycline (tet)-inducible promoter.
Reiss, Martina
core
Advanced Science, EarlyView.Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu +34 more
wiley +1 more source
Infection and Drug Resistance, 2021 Witawat Tunyong,1 Weewan Arsheewa,2 Sirijan Santajit,3,4 Thida Kong-ngoen,1 Pornpan Pumirat,1 Nitat Sookrung,5,6 Wanpen Chaicumpa,6 Nitaya Indrawattana1 1Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok,
Tunyong W +7 more
doaj
An analysis of the FIR/RADIO Continuum Correlation in the Small Magellanic Cloud
, 2012 The local correlation between far-infrared (FIR) emission and radio-continuum (RC) emission for the Small Magellanic Cloud (SMC) is investigated over scales from 3 kpc to 0.01 kpc. Here, we report good FIR/RC correlation down to ~15 pc.
A. Hughes +61 more
core +1 more source
Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis
Advanced Science, EarlyView.Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu +13 more
wiley +1 more source
What’s the Difference: A Study of the Nature and Extent of Racism in Rugby League [PDF]
, 1995 At the start of the 1993/4 season the Commission for Racial Equality (CRE) and the Professional Footballers' Association launched the 'Let's Kick Racism Out of Football' campaign which subsequently gained the support of the Football Association, the FA ...
Carrington, B +3 more
core