Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME
Advanced Functional Materials, EarlyView.A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li +10 more
wiley +1 more source
The Evolving Applications of Creatine Supplementation: Could Creatine Improve Vascular Health?
Nutrients, 2020 Creatine is a naturally occurring compound, functioning in conjunction with creatine kinase to play a quintessential role in both cellular energy provision and intracellular energy shuttling.
H. Clarke +4 more
semanticscholar +1 more source
Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System
Advanced Functional Materials, EarlyView.A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim +4 more
wiley +1 more source
Detection of Metabolites by Proton Ex Vivo NMR, in Vivo MR Spectroscopy Peaks and Tissue Content Analysis: Biochemical-Magnetic Resonance Correlation: Preliminary Results [PDF]
, 2009 *Aim*: Metabolite concentrations by in vivo magnetic resonance spectroscopy and ex vivo NMR spectroscopy were compared with excised normal human tissue relaxation times and tissue homogenate contents. *Hypothesis*: Biochemical analysis
Arun Agrawala +2 more
core +1 more source
Advanced Functional Materials, EarlyView.ABSTRACT Engineering living matter has great clinical potential to deliver functional replacement organs. However, clinical translation remains hampered by the current inability to maintain viability of clinically relevant‐sized constructs. During the pre‐vascular phase, implants rely on nutrient diffusion for survival, which is insufficient at ...
Melvin Gurian +5 more
wiley +1 more source
Vergleich dreier Ringversuche zur radioimmunologischen Thyrotropin-Bestimmung nach dem "Münchner Modell" [PDF]
, 1983 Peer ...
Habermann, J. +5 more
core +2 more sources
Creatine uptake regulates CD8 T cell antitumor immunity
Journal of Experimental Medicine, 2019 Di Biase et al. show for the first time that creatine acts as a “molecular battery” conserving bioenergy to power CD8 T cell activities; that creatine uptake is critical in supporting antitumor T cell immunity; and that creatine supplementation holds ...
S. Di Biase +11 more
semanticscholar +1 more source
Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels
Advanced Healthcare Materials, EarlyView.We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa +8 more
wiley +1 more source
On the role of the oxidation in the methylation of guanidoacetic acid [PDF]
, 1947 There are two, at least, methyl transfer reactions promoted by liver slices in vitro (2).
Borsook, Henry, Dubnoff, Jacob W.
core
Supplement use in sport: is there a potentially dangerous incongruence between rationale and practice? [PDF]
, 2007 BACKGROUND: Supplement use by athletes is complex and research supports the alarming notion of misinformed decisions regarding supplements. HYPOTHESIS: A frequent divergence between the type of supplements chosen by athletes and the rationale dictating ...
Naughton, Declan, Petróczi, Andrea
core +2 more sources