Results 91 to 100 of about 149,310 (234)

TWEAK/Fn14 signaling drives oxidative cardiac injury in systemic lupus erythematosus: Evidence from patient biomarker studies, lupus mouse models, and cardiomyocyte assays

Arthritis &Rheumatology, Accepted Article.
Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/Fn14 signaling in SLE‐related cardiomyopathy and its potential as a ...
Yale Liu, Zhu Yan, Xueting Peng, Meixuan Li, Juan Wang, Yan Zhang, Xiaoqian Hu, Mingzhu Zhou, Kaixuan Ren, Dan Zhang, Xingyi Guo, Yumin Xia, Huanhuan Huo   +12 more
wiley   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Effects of maternal supplementation of guanidinoacetic acid on skeletal muscle growth and metabolism in beef offspring

Frontiers in Animal Science
Guanidinoacetic acid (GAA) is a precursor of creatine and is an arginine-sparing compound that may improve energy metabolism and muscle growth. Its potential in beef cow–calf systems, however, is still poorly understood.
Luiza V. Kladt, Thaís C. Costa, Luiz C. O. Sousa, Marta M. Santos, Jenifer K. C. Varizi, Livia S. Rodrigues, Luiz J. M. Motta, Walmir Silva, Pedro V. R. Paulino, Tales L. Resende, Claudia B. Sampaio, Mateus P. Gionbelli, Marcio S. Duarte, Marcio S. Duarte   +13 more
doaj   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

Impact of Creatine Supplementation on Muscle and Bone Strength in Older Adults: A Narrative Review

Journal of Education, Health and Sport
Introduction and purpose: Age-related declines in skeletal muscle mass and strength, together with bone loss, reduce physical performance and increase frailty and fall risk in older adults.
Pawel Michalak, Konrad Borowski, Oskar Pastuszek, Maja Radziwon, Emilia Bolesta-Okuniewska, Aleksandra Marchwińska-Pancer, Katarzyna Kopeć, Julia Ceryn, Anna Wicher   +8 more
doaj   +1 more source

Feasibility and Safety of the ETcath200 Robotic PCI System for Complex Coronary Lesions: A Prospective Single‐Center Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background International robotic‐assisted PCI platforms such as CorPath 200 and CorPath GRX have demonstrated procedural safety and efficacy but are limited by the absence of real‐time tactile feedback and cumbersome device exchange. The ETcath200, the first domestically developed robotic PCI system in China, introduces guidewire force‐sensing
Jing Yang, Yuqi Fang, Yizhu Yan, Zijing Liu, Jing Xie, Ge Zhang, Zhicheng Zhang, Tienan Sun, Guangyao Zhai   +8 more
wiley   +1 more source

Effects of six weeks of high-dose creatine monohydrate supplementation with or without guanidinoacetic acid on homocysteine and markers of health

Journal of the International Society of Sports Nutrition
Background Guanidinoacetic acid (GAA) is the precursor to creatine. Preliminary studies indicate that GAA supplementation (e.g. 2–3 g/d for 4 weeks) can increase brain creatine to a similar degree as higher amounts of CrM.
Khatereh Babakhani, Jisun Chun, Drew E. Gonzalez, Broderick Dickerson, Ryan Sowinski, Christopher J. Rasmussen, Richard B. Kreider   +6 more
doaj   +1 more source

Construction of a CO2‐Fixing Compartment Using a Shape‐Transforming DNA Scaffold

Chemistry – A European Journal, EarlyView.
A shape‐transforming DNA scaffold encapsulates RuBisCO within a controllable, self‐contacting compartment that mimics the carboxysome. The scaffold switches between open and closed states, enabling direct comparison of identical enzyme populations in different microenvironments.
Hui Yang, Peng Lin, Surachada Chuaychob, Huyen Dinh, Mei Nakabayashi, Eiji Nakata, Takashi Morii   +6 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Epilepsy characteristics in patients with muscle‐eye‐brain disease: A systematic review of electroclinical features

Epileptic Disorders, EarlyView.
Abstract Background and Objectives Muscle‐Eye‐Brain disease (MEB) is a dystroglycanopathy that belongs to the congenital muscular dystrophies. Central nervous system manifestations include congenital brain abnormalities, neurodevelopmental delay, and epilepsy, making it a rare but important cause of developmental and epileptic encephalopathy.
Stefania Kalampokini, Evripidis Pityrigkas, Eleni Liouta, Georgia Pepe, Vasiliki Poulidou, Martha Spilioti, Vasilios K. Kimiskidis   +6 more
wiley   +1 more source