Results 81 to 90 of about 196,498 (290)

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Creatine as an essential pharmaconutrient in the practice of training athletes in martial arts

Сучасні медичні технології
Aim: to form modern ideas about the properties of creatine as a pharmaconutrient, its biological role in the body, and rational dosage during physical exertion. Materials and methods.
I. B. Samura, L. M. Gunina-Orlova, O. I. Orlov, A. M. Hurieieva, O. Ye. Chernenko, K. Milashus   +5 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Case report of an exercise training and nutritional intervention plan in a patient with A350P mutation in DES gene

Clinical Case Reports, 2020
Performing a supplementation intervention with creatine and protein, in conjunction with low‐intensity endurance and resistance exercise is safe and has a positive effect on the quality of life in a patient with desminopathy.
Camila Monje, Sebastian Jannas‐Vela, Keith Baar, Hermann Zbinden‐Foncea   +3 more
doaj   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

The phospho-creatine Circuit: Molecular and cellular physiology of creatine kinases, sensitivity to free radicals and enhancement by creatine supplementation

, 2007
International audienceEvidence for the important physiological role of the creatine kinase (CK)- phosphocreatine (PCr) system in energy homeostasis in sarcomeric muscle, brain, and other organs of high and fluctuating energy requirements is presented in ...
Schlattner, Uwe, Widmer, Hans Rudolf, Neumann, Dietbert, Wallimann, T, Epand, RM, Schlattner, U, Wallimann, Theo, Epand, RF, Saks, V, Neumann, D, Agarkova, I, Epand, Richard, M., Andres, Robert, H., Tokarska-Schlattner, Malgorzata, Hornemann, Thorsten, Andres, RH, Tokarska-Schlattner, M, Widmer, HR, Epand, Raquel, F., Saks, Valdur, Agarkova, Irina   +20 more
core   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Effects of maternal supplementation of guanidinoacetic acid on skeletal muscle growth and metabolism in beef offspring

Frontiers in Animal Science
Guanidinoacetic acid (GAA) is a precursor of creatine and is an arginine-sparing compound that may improve energy metabolism and muscle growth. Its potential in beef cow–calf systems, however, is still poorly understood.
Luiza V. Kladt, Thaís C. Costa, Luiz C. O. Sousa, Marta M. Santos, Jenifer K. C. Varizi, Livia S. Rodrigues, Luiz J. M. Motta, Walmir Silva, Pedro V. R. Paulino, Tales L. Resende, Claudia B. Sampaio, Mateus P. Gionbelli, Marcio S. Duarte, Marcio S. Duarte   +13 more
doaj   +1 more source

The effect of creatine supplementation on myocardial function, mitochondrial respiration and susceptibility to ischaemia/reperfusion injury in sedentary and exercised rats

, 2012
ArticleAim: To investigate the effects of dietary creatine supplementation alone and in combination with exercise on basal cardiac function, susceptibility to ischaemia/reperfusion injury and mitochondrial oxidative function.
Webster I, Du Toit E.F., du Toit EF, Huisamen B, Lochner A., Lochner A, Webster I., Huisamen B.   +7 more
core   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source