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Cataloguing guanidinoacetic acid content in nutritional supplements [PDF]
Food Science & Nutrition, 2022 AbstractGuanidinoacetic acid (GAA, also known as glycocyamine or guanidinoacetate) is a naturally occurring alpha amino acid derivative and newly recognized dietary compound obtainable by different foods and nutritional supplements. Anecdotal evidence suggests that the GAA exposure from supplements might be a major source of GAA supply, out‐competing ...
Sergej M. Ostojic +3 more
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Human skeletal muscle contains no detectable guanidinoacetic acid [PDF]
Applied Physiology, Nutrition, and Metabolism, 2018 We analyzed data from previously completed trials to determine the effects of supplemental guanidinoacetic acid (GAA) on markers of muscle bioenergetics in healthy men using 1.5 T magnetic resonance spectroscopy. No detectable GAA (<0.1 μmol/L) was found in the vastus medialis muscle at baseline nor at follow-up.
Ostojic, Sergej M., Ostojic, Jelena
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Guanidinoacetic Acid as a Nutritional Adjuvant to Multiple Sclerosis Therapy
Frontiers in Human Neuroscience, 2022 Tackling impaired bioenergetics in multiple sclerosis (MS) has been recently recognized as an innovative approach with therapeutic potential. Guanidinoacetic acid (GAA) is an experimental nutrient that plays a significant role in high-energy phosphate metabolism.
Sergej M. Ostojic +2 more
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Guanidinoacetic acid in human nutrition: Beyond creatine synthesis [PDF]
Food Science & Nutrition, 2023 AbstractGuanidinoacetic acid (GAA) is a nutrient that has been used in human nutrition since the early 1950s. Recommended for its role in creatine biosynthesis, GAA demonstrated beneficial energy‐boosting effects in various clinical conditions. Dietary GAA has also been suggested to trigger several creatine‐independent mechanisms.
Sergej M. Ostojic, Jagoda Jorga
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Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy? [PDF]
Nutrients, 2021 Guanidinoacetic acid (GAA) is a natural amino acid derivative that is well-recognized for its central role in the biosynthesis of creatine, an essential compound involved in cellular energy metabolism. GAA (also known as glycocyamine or betacyamine) has been investigated as an energy-boosting dietary supplement in humans for more than 70 years.
Ostojic, Sergej, Sergej M. Ostojic
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PLOS ONE, 2022 Guanidinoacetic acid (GAA) is the only precursor for the creatine synthesis of vertebrates. Creatine (Cr) and phosphocreatine (PCr) are able to provide energy for the rapid growth and development of the muscle tissue. This study evaluated the effects of dietary different levels GAA on growth performance, GAA absorption and creatine metabolism of lambs.
Shiqi Zhang +7 more
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Biosynthesis of Guanidinoacetic Acid in Isolated Renal Tubules [PDF]
Clinical Chemistry and Laboratory Medicine, 1992 Guanidinoacetic acid, a precursor of creatine, is an essential substrate for muscle energy metabolism. Since guanidinoacetic acid has been reported to be synthesized from arginine and glycine by glycine amidinotransferase (transamidinase) in kidney homogenates or slices, the purpose of this study was to provide evidence of guanidinoacetic acid ...
Takeda, Michio +4 more
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Co-administration of methyl donors along with guanidinoacetic acid reduces the incidence of hyperhomocysteinaemia compared with guanidinoacetic acid administration alone [PDF]
British Journal of Nutrition, 2013 Guanidinoacetic acid (GAA) is the natural biosynthetic precursor of creatine, in a metabolic reaction that requires only a methyl group transfer. The use of GAA as a food additive for restoring creatine load in human tissues is rather unexplored and data on efficacy and safety are limited.
Sergej M, Ostojic +3 more
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Urinary Excretion Rate of Guanidinoacetic Acid in Essential Hypertension [PDF]
Nephron, 1989 The kidney is one of the major target organs in hypertension. Longterm persistent hypertension causes nephrosclerosis pathologicaly in 70–90% of patients1–2. Concerning the laboratory findings correlated with this pathological change, urinary micro-albumin (mAlb), s-2-microglobuline (RMG) and N-acetyl-D-glucosaminidase (NAG) have been reported as early
Y, Takano +4 more
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Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.Encapsulated sodium butyrate outperforms its non‐encapsulated form by enhancing gut health, reducing oxidative stress and pulmonary hypertension and improving carcass yield in broilers exposed to high‐altitude cold stress, offering an effective nutritional strategy for challenging environments.
Behnam Ahmadipour +3 more
wiley +1 more source