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Creatine, Creatine Kinase, and Aging

2018
With an ever aging population, identifying interventions that can alleviate age-related functional declines has become increasingly important. Dietary supplements have taken center stage based on various health claims and have become a multi-million dollar business.
Nathalie, Sumien   +2 more
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Creatine Kinase

CRC Critical Reviews in Clinical Laboratory Sciences, 1982
Creatine kinase is present in significant concentrations in skeletal muscle and cardiac muscle and to a lesser extent in gastrointestinal tract and brain tissue. The enzyme has been purified from a variety of tissues and an examination of its kinetic and physical properties reveal that the enzyme consists of two subunits and can exist as three ...
R, Bais, J B, Edwards
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Creatine Supplementation

Current Sports Medicine Reports, 2013
Creatine monohydrate is a dietary supplement that increases muscle performance in short-duration, high-intensity resistance exercises, which rely on the phosphocreatine shuttle for adenosine triphosphate. The effective dosing for creatine supplementation includes loading with 0.3 g·kg·d for 5 to 7 days, followed by maintenance dosing at 0.03 g·kg·d ...
Matthew, Hall, Thomas H, Trojian
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Creatine as an antioxidant

Amino Acids, 2011
Creatine monohydrate (Cr), the most diffuse supplement in the sports industry, is receiving greater attention because of its beneficial effects in a wide number of human degenerative diseases and conditions. These effects can be barely explained on the basis of the sole ergogenic role of the Cr/CrP system.
SESTILI, PIERO   +6 more
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Creatine metabolism and the consequences of creatine depletion in muscle

Molecular and Cellular Biochemistry, 1994
Currently, considerable research activities are focussing on biochemical, physiological and pathological aspects of the creatine kinase (CK)-phosphorylcreatine (PCr)-creatine (Cr) system (for reviews see [1,2]), but only little effort is directed towards a thorough investigation of Cr metabolism as a whole.
M, Wyss, T, Wallimann
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Creatine in Humans with Special Reference to Creatine Supplementation

Sports Medicine, 1994
Since the discovery of creatine in 1832, it has fascinated scientists with its central role in skeletal muscle metabolism. In humans, over 95% of the total creatine (Crtot) content is located in skeletal muscle, of which approximately a third is in its free (Crf) form. The remainder is present in a phosphorylated (Crphos) form. Crf and Crphos levels in
P D, Balsom, K, Söderlund, B, Ekblom
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Pharmacokinetics of Creatine

2007
Research has demonstrated that creatine supplementation has some therapeutic benefit with respect to muscle function and more recently neurological function. Despite the growing body of literature on the pharmacologic effect of creatine, very little is known about the disposition of creatine after supraphysiologic doses.
Wesley, McCall, Adam M, Persky
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Muscle creatine uptake and creatine transporter expression in response to creatine supplementation and depletion

Journal of Applied Physiology, 2003
The total creatine pool size [Crtotal; creatine (Cr) + phosphocreatine (PCr)] is crucial for optimal energy utilization in skeletal muscle, especially at the onset of exercise and during intense contractions. The Crtotallikely is controlled by long-term modulation of Cr uptake via the sodium-dependent Cr transporter (CrT).
Jeffrey J, Brault   +2 more
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The Creatine-Creatine Phosphate Shuttle for Energy Transport — Compartmentation of Creatine Phosphokinase in Muscle

1982
There are two viewpoints regarding the role of the enzyme creatine Phosphokinase (CPK), which catalyzes the reversible transphosphorylation of creatine and adenine nucleotides in energy transport. The classical viewpoint (Fig. 1) regards CPK as a near equilibrium enzyme buffering cytosolic changes in nucleotide concentration (1,2), with creatine ...
S, Erickson-Viitanen   +3 more
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Creatine and Creatine Kinase in Health and Disease

2007
Creatine and creatine kinase in health and disease / , Creatine and creatine kinase in health and disease / , کتابخانه دیجیتال جندی شاپور ...
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