Results 131 to 140 of about 1,019,575 (429)

Paracetamol and its metabolites in children and adults with spinal muscular atrophy – a population pharmacokinetic model

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of the study was to investigate whether differences in paracetamol pharmacokinetics (PK) between spinal muscular atrophy (SMA) patients and healthy controls (HC) could be attributed to specific clinical covariates. Methods Nonlinear mixed‐effects modelling (NONMEM 7.4) was used to develop a population PK model, explore covariates ...
Qiaolin Zhao, Marie Mostue Naume, Brenda C. M. de Winter, Thomas Krag, Sissel Sundell Haslund‐Krog, Karoline Lolk Revsbech, John Vissing, Helle Holst, Morten Hylander Møller, Tessa Munkeboe Hornsyld, Morten Dunø, Christina Engel Hoei‐Hansen, Alfred Peter Born, Per Bo Jensen, Mette Cathrine Ørngreen   +14 more
wiley   +1 more source

Ungated, plug-and-play preclinical cardiac CEST-MRI using radial FLASH with segmented saturation [PDF]

Purpose: ECG and respiratory-gated preclinical cardiac CEST-MRI acquisitions are difficult due to variable saturation recovery with T1, RF interference in the ECG signal, and offset-to-offset variation in Z-magnetization and cardiac phase introduced by changes in cardiac frequency and trigger delays.
arxiv   +1 more source

Identification of proteins in the postsynaptic density fraction by mass spectrometry [PDF]

, 2000
Our understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the postsynaptic density (PSD) fraction, a subcellular fraction enriched in structures with the morphology ...
Jensen, Ole N., Kennedy, Mary B., Mann, Matthias, Mercer, John A., Provance, D. William, Jr., Walikonis, Randall S.   +5 more
core   +2 more sources

Creatine kinase monitoring in sport medicine.

British Medical Bulletin, 2007
UNLABELLED AREAS OF GENERAL AGREEMENT: Total creatine kinase (CK) levels depend on age, gender, race, muscle mass, physical activity and climatic condition.
P. Brancaccio, N. Maffulli, F. Limongelli   +2 more
semanticscholar   +1 more source

An open‐label, single‐arm, multicenter, phase II trial of bireociclib as monotherapy for heavily pretreated HR‐positive, HER2‐negative advanced breast cancer patients: BRIGHT‐1 trial

Cancer Communications, EarlyView.
Abstract Background Bireociclib (XZP‐3287) is a novel selective cyclin‐dependent kinase 4 and 6 (CDK4/6) inhibitor, with a favorable safety profile demonstrated in preclinical and phase I studies. BRIGHT‐1 aimed to further explore the efficacy and safety of bireociclib monotherapy in patients with locally advanced, recurrent or metastatic, hormone ...
Jiayu Wang, Qingyuan Zhang, Tao Sun, Huiping Li, Ying Cheng, Zhongsheng Tong, Huihui Li, Wei Li, Jingfen Wang, Yuee Teng, Xinhong Wu, Jing Cheng, Zhendong Chen, Zhengqiu Zhu, Li Wang, Mingming Liu, Xianghui Duan, Lingmei Xu, Binghe Xu   +18 more
wiley   +1 more source

Correlation of anti-signal recognition particle autoantibody levels with creatine kinase activity in patients with necrotizing myopathy.

Arthritis & Rheumatism, 2011
OBJECTIVE Anti-signal recognition particle (anti-SRP) autoantibodies are associated with severe acquired necrotizing myopathies. The role of these autoantibodies remains elusive, and the evolution of anti-SRP levels over time is unknown.
O. Benveniste, L. Drouot, F. Jouen, J. Charuel, C. Bloch-Queyrat, A. Béhin, Z. Amoura, I. Marie, M. Guiguet, B. Eymard, D. Gilbert, F. Tron, S. Herson, L. Musset, O. Boyer   +14 more
semanticscholar   +1 more source

Identification of Biallelic dystrophin gene variants during maternal carrier testing for Becker muscular dystrophy and review of the DMD exon 49–51 deletion phenotype

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
This manuscript summarizes a case of biallelic dystrophin (DMD) variants in a mildly affected female patient and additionally highlights the phenotypic spectrum of one of the patient's two DMD variants, a deletion of exons 49–51. This deletion previously had few reports in the published literature, despite its frequency within our institution's ...
Elizabeth A. Ulm, Chinmayee B. Nagaraj, Cuixia Tian, Teresa A. Smolarek   +3 more
wiley   +1 more source

Role of increase of MB-creatine kinase in different extracardiac pathologies

Лечащий Врач, 2021
Traditionally, increase of activity of creatine kinase MB-fraction (CK‑MB) is a diagnostic marker of acute myocardial infarction, but also registered in other diseases, when there are no lesions of coronary arteries. In some patients, the values of CK-MB
T. A. Ruzhentsova, E. I. Mileykova, A. V. Mozhenkova, Yu. V. Novozhenova, O. M. Kobyzeva, V. A. Dubravitsky, L. L. Grebets, N. A. Meshkova   +7 more
doaj  

A Novel Bis-Coumarin Targets Multiple Tyrosine Kinases of Key Signaling Pathways in Melanoma and Inhibits Melanoma Cell Survival, Proliferation, and Migration [PDF]

arXiv, 2020
Melanoma is one of the most dangerous skin malignancies due to its high metastatic tendency and high mortality. Activation of key signaling pathways enforcing melanoma progression depends on phosphorylation of tyrosine kinases, and oxidative stress. We here investigated the effect of the new bis-coumarin derivative (3,5-DCPBC) on human melanoma cell ...
arxiv  

Efek Paparan Arus Listrik terhadap Jumlah Titik Hiperkontraksi Otot Jantung dan Kadar Kreatin Kinase - MB Serum Tikus Wistar [PDF]

, 2011
Background: Electrocution can cause damages in tissue and body biochemical changes including heart muscles hypercontraction and elevation of creatine kinase–MB serum level.
Relawati, Ratna
core