Thoracic Cancer, Volume 14, Issue 1, Page 68-72, January 2023., 2023 Abstract Objective Our study evaluated the renal safety of abemaciclib plus endocrine therapy (ET) with bisphosphonate as a treatment option for hormone receptor positive, human epidermal growth factor receptor 2 (HER‐2) negative (HR+/HER2−) advanced breast cancer (ABC), especially with bone metastasis.
Chunfang Hao +4 more
wiley +1 more source
Integration of Genetic Algorithms and Deep Learning for the Generation and Bioactivity Prediction of Novel Tyrosine Kinase Inhibitors [PDF]
arXivThe intersection of artificial intelligence and bioinformatics has enabled significant advancements in drug discovery, particularly through the application of machine learning models. In this study, we present a combined approach using genetic algorithms and deep learning models to address two critical aspects of drug discovery: the generation of novel
arxiv
Creatine Kinase, Creatine Kinase‑MM, and the Isoforms of Creatine Kinase‑MM Following a Competitive Swimming Workout [PDF]
, 1991 Serum levels of total creatine kinase (CK), CK-MM and the isoform of CD-MM were measured in 14 male competitive collegiate swimmers. The purpose of this study was to observe changes in CK and the isoforms of CK-MM following a competitive swim training ...
Bean, Mark H. +5 more
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The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
Nature Network Boston, 2017 Nina Fenouille +20 more
semanticscholar +1 more source
Presence of creatine kinase BB isoenzyme in some patients with prostatic carcinoma. [PDF]
, 1977 Ronald Feld, David L. Witte
openalex +1 more source
4‐phenylbutyric acid—Identity crisis; can it act as a translation inhibitor?
Aging Cell, Volume 21, Issue 12, December 2022., 2022 4PBA is a weak inhibitor of mRNA translation, and it does not directly promote protein folding nor prevents aggregation. Instead, it possibly alleviates proteostatic or ER stress by inhibiting protein synthesis, allowing the cells to cope with misfolded proteins by reducing protein load.
Daniel Stein +6 more
wiley +1 more source
Higher Levels of Creatine Kinase MB (CK-MB) Than Total Creatine Kinase (CK): A Biochemistry Reporting Error or an Indicator of Other Pathologies? [PDF]
Cureus, 2023 Ghosh A, Datta P, Dhingra M.
europepmc +1 more source
Studies on the Localization and Mechanism of Alkaline Metal Activation of Protein Synthesis [PDF]
Localization and mechanism of rat liver protein synthesis by alkali metals and ammonium ...
Leon, H. A., Speer, H. L.
core +1 more source
Determination of creatinine and creatine by capillary electrophoresis : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Chemistry at Massey University [PDF]
, 1998 The assessment of creatinine and creatine in biological fluids is important in the evaluation of renal and muscular functions. For routine creatinine determinations in the clinical laboratory, the most frequently used method is the spectrophotometric one
Guo, Hong
core