Results 101 to 110 of about 612,233 (251)

Venous blood lactate concentration as a predictor of intestinal viability in horses with acquired indirect inguinal hernia

Equine Veterinary Journal, EarlyView.
Abstract Background Acquired indirect inguinal hernia represents a life‐threatening emergency. Therapeutic decision‐making largely depends on intestinal viability, for which specific predictive parameters (such as venous lactate) have not been evaluated.
Raquel Rivero‐García, Cristina Andreu‐Vázquez, Beatriz Fuentes‐Romero, Pablo Fernández‐Hernández, María Luisa Rodríguez‐Pozo, Ignacio Aguilar Sebastián, Salvador Termes Soto, Mercedes Martínez Gallardo, Manuel Iglesias‐García   +8 more
wiley   +1 more source

Composition of allogeneic equine orthobiologics and their repeated intra‐articular administrations

Equine Veterinary Journal, EarlyView.
Abstract Background Orthobiologics such as platelet‐rich plasma (PRP) and alpha‐2‐macroglobulin (A2MG) are increasingly used for equine musculoskeletal injuries. However, their composition and safety with repeated allogeneic intra‐articular administration remain poorly investigated.
Yanne Van Reusel, Sarah Y. Broeckx, Anna Carolo, Marco Patruno, Jonas Steenbrugge, Jimmy Saunders, Enrico Gugliandolo, Jan H. Spaas   +7 more
wiley   +1 more source

Screening for primary creatine deficiencies in French patients with unexplained neurological symptoms

Orphanet Journal of Rare Diseases, 2012
A population of patients with unexplained neurological symptoms from six major French university hospitals was screened over a 28-month period for primary creatine disorder (PCD).
Cheillan David, Curt Marie Joncquel-Chevalier, Briand Gilbert, Salomons Gajja S, Mention-Mulliez Karine, Dobbelaere Dries, Cuisset Jean-Marie, Lion-François Laurence, Portes Vincent Des, Chabli Allel, Valayannopoulos Vassili, Benoist Jean-François, Pinard Jean-Marc, Simard Gilles, Douay Olivier, Deiva Kumaran, Afenjar Alexandra, Héron Delphine, Rivier François, Chabrol Brigitte, Prieur Fabienne, Cartault François, Pitelet Gaëlle, Goldenberg Alice, Bekri Soumeya, Gerard Marion, Delorme Richard, Tardieu Marc, Porchet Nicole, Vianey-Saban Christine, Vamecq Joseph   +30 more
doaj   +1 more source

Current and potential new treatment strategies for creatine deficiency syndromes.

, 2022
Creatine deficiency syndromes (CDS) are inherited metabolic disorders caused by mutations in GATM, GAMT and SLC6A8 and mainly affect central nervous system (CNS).
Fernandes-Pires, G., Braissant, O.
core   +1 more source

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source

Synthesis and Biological Evaluation of New Creatine Fatty Esters Revealed Dodecyl Creatine Ester as a Promising Drug Candidate for the Treatment of the Creatine Transporter Deficiency

, 2016
The creatine transporter deficiency is a neurological disease caused by impairment of the creatine transporter SLC6A8, resulting in mental retardation associated with a complete absence of creatine within the brain and cellular energy perturbation of ...
Aloïse Mabondzo (1942075), Alexandra Trotier-Faurion (1942078), Frédéric Taran (1688335), Vassili Valayannopoulos (1942084), Pascale de Lonlay (1942081), Sophie Dézard (1942072)   +5 more
core   +1 more source

Implantable electrochemical sensors for continuous blood monitoring

FlexMat, EarlyView.
Implantable electrochemical sensors enable direct, in situ, and continuous blood monitoring, shifting diagnosis from population‐based averages to dynamic, individualized analysis. This review systematically examines the influence of the unique blood properties on sensor design.
Kuangyi Zou, Yuanzhen Wang, Haidong Wang, Ye Zhang   +3 more
wiley   +1 more source

Neuropsychological profile and clinical effects of arginine treatment in children with creatine transport deficiency

Orphanet Journal of Rare Diseases, 2012
Background SLC6A8, an X-linked gene, encodes the creatine transporter (CRTR) and its mutations lead to cerebral creatine (Cr) deficiency which results in mental retardation, speech and language delay, autistic-like behaviour and epilepsy (CRTR-D, OMIM ...
Chilosi Annamaria, Casarano Manuela, Comparini Alessandro, Battaglia Francesca, Mancardi Margherita, Schiaffino Cristina, Tosetti Michela, Leuzzi Vincenzo, Battini Roberta, Cioni Giovanni   +9 more
doaj   +1 more source

Effects of whey isolate, creatine and resistance training on muscle hypertrophy [PDF]

, 2007
PURPOSE: Studies that have attributed gains in lean body mass to dietary supplementation during RE training have not reported these changes alongside adaptations at the cellular and sub-cellular levels. Therefore, the purpose of this study was to examine
Carey, Michael F, Hayes, Alan, Williams, Andrew D, Cribb, Paul J, Stathis, Christos   +4 more
core   +2 more sources

Stage- and Region-Dependent Proteomic Alterations in a Mouse Model of Creatine Transporter Deficiency

Journal of Neuroscience
SLC6A8 encodes the creatine transporter (CRT), which mediates creatine transport across the plasma membrane in the brain, including the blood–brain barrier and neurons. Creatine transporter deficiency (CTD), caused by pathogenic variants in SLC6A8, leads
Shingo Ito, Y. Iwata, Tatsuki Uemura, Michihiko Sugimoto, Haruka Kumabe, Ayaka Miyano, Teruya Nakamura, Naoto Tashiro, M. Ieiri, Moeka Umezaki, Shoma Chikamatsu, Takeshi Masuda, Satohiro Nakao, Naomi Nakagata, T. Takeo, Kimi Araki, S. Ohtsuki   +16 more
semanticscholar   +1 more source