Results 111 to 120 of about 2,126,239 (289)
Staying creative: creative technique, habit and experience [PDF]
, 2016 This chapter focuses analysis on a practice-based research project exploring personal creativity in musical composition. Seeking simply to explore the process and experience of creative routines in a more focused way―most specifically through imposed ...
Brown, Michael, Wilson, Chris
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Inventing (in) early geometry, or How creativity inheres in the doing of mathematics
REDIMAT, 2015 Inventing is fundamental to mathematical activity, should one be a professional mathematician or a primary school student. Research on mathematical creativity generally is organized along three axes according to its focus on the final product, the ...
Jean-Francois Maheux, Wolf-Michael Roth
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
FREEDOM OF CREATIVITY AND CREATIVE IMAGINATION. MAN AND HIS TIME
Высшее образование в России, 2018 Man as a creative personality desires for freedom as well as cognition and creative work as his essence. It should be noted, however, that what we know about ourselves and how we see ourselves are far from being the same thing.
A. E. Razumov
doaj
Current Research in Environmental SustainabilityA national study in Ireland on the impacts of creative and cultural climate action initiatives highlights their potential to act as catalysts for fostering citizen engagement.
J. Mac Mahon +4 more
doaj +1 more source
Teaching and Professional Fellowship Report 2004/5 : Designing effective curriculum for dyslexic students within Art and Design in Higher Education [PDF]
, 2005 In the first instance, it is worthwhile examining the context for curriculum changes in 2005. The Higher Education Statistics Agency in 2004 recorded the number of dyslexic undergraduates in the U.K.
Symonds, Heather
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source