Results 111 to 120 of about 120,682 (305)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Networks in the shadow of markets and hierarchies : calling the shots in the visual effects industry
, 2009 The nature and organisation of creative industries and creative work has increasingly been at the centre of academic and policy debates in recent years.
Parker, Rachel +5 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Creative Act as a Meta-Historical One. Nicolas Berdyaev’s Concept
, 2013 The article constitutes an attempt to analyse the interrelation between two central categories of Berdyaev’s philosophy – creative act and meta-history.
Jakubowski, Jarosław
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Word-formation at the crossroads of productivity, creativity, and structural complexity
LinguisticsProductivity has long been one of the central topics in the study of word-formation. Research in this area has primarily focused on affixation and treated it independently of the creative performance of language users. This paper offers new insights into
Körtvélyessy Lívia
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Creative approaches to primary physical education
, 2018 In this chapter, I wish to argue that teaching physical education; learning to move and moving to learn www.afpe.org.uk)), is itself a creative act, rather akin to a creative performance that is based on expertise, structure and facilitation.
Pickard, A.
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Musical imagery in the creative process
, 2012 We know that music a person has heard in the past can be retrieved from memory and mentally re-experienced with high precision and accuracy. Most people, including those without musical training, fall victim to ‘earworms’ 1 and can acknowledge the ...
Bailes, Freya (R12191) +1 more
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