Results 41 to 50 of about 100,185 (258)
Exploring Vital Energy at Work; The Role of Employee Agility and Creativity
This research is addressing how vitality, in form of proactive vitality management can boost creative performance through employee agility. The existing literature on the relationship between these three variables is still limited.
Bella Carissa, Endang Parahyanti
doaj +1 more source
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Embracing the Radical Cartographies of the Doggy Dérive
Operating at the intersection of fine art walking practice, psychogeography, and critical animal studies, the practice of Deep Canine Topography seeks to reframe the humble act of the walk-ies as a co-authored, multi-species act of making and performing
Darren O'Brien
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OD-CZUWANIE – ISTOTA TWÓRCZOŚCI [PDF]
This is the question I undertake: does – in its essence – the creative process consist in performing or in-feeling sympathy? On which side is one to locate the creative act?
Janusz Krupiński
doaj
Design and Make: Translations between the Imagined, the Perceived and the Executed
According to Schön (1987), design is a form of artistry and making, where learning about a specific topic or design emerges through actions (conscious and unconscious) and heuristics.
Diego Pinochet
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source

