Results 41 to 50 of about 116,703 (258)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Exploring Vital Energy at Work; The Role of Employee Agility and Creativity
Jurnal Penelitian Pendidikan, Psikologi dan KesehatanThis research is addressing how vitality, in form of proactive vitality management can boost creative performance through employee agility. The existing literature on the relationship between these three variables is still limited.
Bella Carissa, Endang Parahyanti
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Embracing the Radical Cartographies of the Doggy Dérive
HumanimaliaOperating at the intersection of fine art walking practice, psychogeography, and critical animal studies, the practice of Deep Canine Topography seeks to reframe the humble act of the walk-ies as a co-authored, multi-species act of making and performing
Darren O'Brien
doaj +1 more source
OD-CZUWANIE – ISTOTA TWÓRCZOŚCI [PDF]
The Polish Journal of Aesthetics, 2003 This is the question I undertake: does – in its essence – the creative process consist in performing or in-feeling sympathy? On which side is one to locate the creative act?
Janusz Krupiński
doaj
Design and Make: Translations between the Imagined, the Perceived and the Executed
Materia Arquitectura, 2016 According to Schön (1987), design is a form of artistry and making, where learning about a specific topic or design emerges through actions (conscious and unconscious) and heuristics.
Diego Pinochet
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source