Results 41 to 50 of about 100,185 (258)

Exploring Vital Energy at Work; The Role of Employee Agility and Creativity

open access: yesJurnal Penelitian Pendidikan, Psikologi dan Kesehatan
This research is addressing how vitality, in form of proactive vitality management can boost creative performance through employee agility. The existing literature on the relationship between these three variables is still limited.
Bella Carissa, Endang Parahyanti
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Embracing the Radical Cartographies of the Doggy Dérive

open access: yesHumanimalia
Operating at the intersection of fine art walking practice, psychogeography, and critical animal studies, the practice of Deep Canine Topography seeks to reframe the humble act of the walk-ies as a co-authored, multi-species act of making and performing
Darren O'Brien
doaj   +1 more source

OD-CZUWANIE – ISTOTA TWÓRCZOŚCI [PDF]

open access: yesThe Polish Journal of Aesthetics, 2003
This is the question I undertake: does – in its essence – the creative process consist in performing or in-feeling sympathy? On which side is one to locate the creative act?
Janusz Krupiński
doaj  

Design and Make: Translations between the Imagined, the Perceived and the Executed

open access: yesMateria Arquitectura, 2016
According to Schön (1987), design is a form of artistry and making, where learning about a specific topic or design emerges through actions (conscious and unconscious) and heuristics.
Diego Pinochet
doaj   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

open access: yes
Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein   +11 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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