Results 131 to 140 of about 724,139 (300)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Developing Critical Thinking Skill Through Text Structure In Esl Reading Classes [PDF]

, 2010
The main purpose of this experimental study was to determine the effects of awareness of the structure of the text on enhancing critical thinking skills in Malaysian undergraduate ESL reading classes.
Heydari, Maryam
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Strengthening Reading and Writing Literacy to Foster Creative Writing Skills at Madrasah Ibtidaiyah

MUDARRISA: Jurnal Kajian Pendidikan Islam
This study aims to describe various reading literacy strengthening activities implemented by Madrasah Ibtidaiyah to foster creative writing skills.  Using a qualitative research method with a case study approach at MIN 1 Banyumas, data was collected through observation, interviews, and documentation.
Nasikhotun Nadiroh, Mikyal Hardiyati, Najihah Abd Wahid   +2 more
openaire   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Arts Corps Program Evaluation Report [PDF]

, 2012
Founded in 2000 on the principle that all young people -- not just those with resources -- should have access to quality arts learning opportunities, Arts Corps is now a leading nonprofit arts education organization in Seattle.
Anne Basham, Mary Murray
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The Effects of Creative Reading Practices on the Skills of Creative

, 2019
Every age has its own unique phenomena forming its social life. In today's information age, this phenomenon is expressed as "producing knowledge". The secret of success in the age of information is to produce new, practical and useful information. In this regard, the human profile that is planned to be trained in the age of information is also required
openaire  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Functional Skills Support Programme: Developing functional skills in art and design [PDF]

, 2010
This booklet is part of "... a series of 11 booklets which helps schools to implement functional skills across the curriculum. The booklets illustrate how functional skills can be applied and developed in different subjects and contexts, supporting ...

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